Study On Visible Light Induced Aminoselenation Of Alkenes

In recent years,with the rapid development and integration of epidemiological,medicinal chemistry and structural chemistry research,scientists understand the importance of organic selenium in the future synthesis field,which has further promoted the development speed and research progress of organic selenium compounds.Because of its special structure and properties,selenide has been widely used in pharmacology,material science and structural chemistry,organic selenium compounds have become one of the research hotspots in the field of synthetic chemistry,which makes it of great fundamental application value.In this paper,a series of 1,2-difunctionalization of alkenes with amines and diselenides were synthesized by using inorganic iron salt as catalyst,at room temperature and otherwise additive-free conditions.Through extensive substrate expansion,57 kinds of selenamine derivatives were synthesized with 23-99% separation yield.Ultravioletvisible absorption demonstrated mixed FeBr₃ and aniline exhibits an absorption maximum at 469 nm,Fluorescence quenching experiment shows that photocatalyst iron bromide reacts with amine to form a key intermediate Fe（Ⅲ）--NH₂-Ph complex,which forms an excited compound by light excitation,and the photoredox quenching process is realized under the action of diselenides compounds.The method successfully realized the synthesis of selenamine derivatives of alkenes by using iron bromide as photocatalyst,in which a large number of primary amines were applied in the reaction system,which exceeded the scope of previous research.The reaction conditions are mild and environmentally friendly,which is in accordance with the principle of atomic economy and the concept of green chemistry.