Construction Of Core Quaternary Carbon Bicyclic Skeleton Of Kopsia Monoterpene Alkaloids Based On Olefin MHAT Reaction

Kopsia monoterpene alkaloids are a large class of indole alkaloids isolated from the Apocynaceae.They have important physiological functions such as anti-tumor,antiinflammatory and anti-malarial activities.Their structures are rich and diverse and have the same biological origin.Under certain conditions,mutual transformation is possible.The purpose of this thesis is to develop a new asymmetric construction method for the quaternary carbon-containing bicyclic skeleton shared by many stamens monoterpene alkaloids.Using chiral ammonium pyroglutamic acid as the starting material and the key conversion of olefin MHAT reaction to realize the asymmetric construction of the core bicyclic skeleton containing quaternary carbon units,the new synthesis of the corresponding asymmetrical alkaloids of multiple stamens,the establishment of the path laid a good foundation.This paper is mainly divided into the following three parts:Chapter 1: Overview of the separation,biological activity and synthesis strategies of the monoterpene alkaloids from the Kopsia Bl;Chapter 2: Application of olefin MHAT reaction in total synthesis of natural products;Chapter 3: Study on a new strategy for the construction of a bicyclic skeleton containing a quaternary carbon core in monoterpene alkaloids from the Kopsia.