Study On Glucose Sensing Properties Of Nano-Copper Hydroxide Modified Electrode

Diabetes is one of the most serious diseases leading to death and disability in the world,and blood glucose is an important indicator of diabetes.Therefore,accurate monitoring and tight control of blood glucose concentration are essential for the correct diagnosis and treatment of diabetes.It is generally known that enzyme glucose sensors have been used for blood glucose detection for a long time.However,due to the inherent shortcomings of enzyme glucose test strips,novel glucose sensors based on enzyme-free catalytic materials have received widespread attention in recent years.In this thesis,a facile electrochemical method is developed to prepare three-dimensional nano-copper hydroxide composites.Their component,structure,and glucose sensing performance are studied by different characterization methods and electrochemical techniques.What’more,the mechanisms for the excellent glucose sensing performance of composites were investigated furtherly.The research content of this thesis is mainly divided into the following three parts.（1）Au@Cu（OH）₂ nanocomposites were prepared by electrodeposition-dealloying method.The as-prepared nanocomposites are composed of gold nanoparticles and copper hydroxide with an unique structure of three-dimensional nanograss.Various electrochemical techniques were used to study the glucose sensing performance of Au@Cu（OH）₂.The results indicated a good sensing performance for glucose was obtained on the modified electrode.The linear（dynamic）range is 0.5 m M to 9.0 m M with a sensitivity of 1.67 m A cm^-2 m M^-1and a detection limit as low as 15.6 n M.（2）Ce O₂-Cu（OH）₂ nanocomposite were facilely synthesized by a three-step method which includes co-plating Ce O₂-Cu Sn alloy,de-alloying of Sn in the alloy and electro-oxidizing.The resulted nanocomposites were confirmed to be composed of Ce O₂ and Cu（OH）₂ by different characterization methods.In addition,cyclic voltammetry and chronoamperometry were used to evaluated the elechemical performance of Ce O₂-Cu（OH）₂.High sensitivity of 2.27 m A cm^-2m M^-1 and low detection limit of 176.6 n M were achieved in a linear（dynamic）range from 0.5m M to 8.5 m M for glucose sensing.Furthermore,reliable results were obtained in the anti-interference test and the analysis of practical samples.（3）A three-electrode integrated flexible glucose sensor device based on Au@Cu（OH）₂nanograss was designed and fabricated.The flexible sensor showed excellent catalytic activity toward glucose.The sensitivity is as high as 7.35 m A cm^-2 m M^-1within a linear range of 0.1m M to 3.3 m M.The detection limit is calculated to be 26.97 n M.The device showed excellent reliability in practical applications which is expected to provide useful direction for the miniaturization and flexibility of glucose sensors in the future.