Studies On Palladium-Catalyzed Tandem Cyclization Borylation Of Alkenes And Borylation/Arylthiolation Of Alkenes

Organoboron compounds are general intermediates in organic synthesis and play an important role in organic chemistry.This thesis mainly studies palladium-catalyzed tandem cyclization borylation of alkenes and copper-catalyzed borylation/arylthiolation of alkenes.Several chapters are included in the following:In the first chapter,we summarized the development of alkenes borylation in recent years involving metal-free hydroboration of alkenes;various transition-metal-catalyzed hydroboration of alkenes,diboration of alkenes,and carboboration,aminoboration of alkenes etc.In the second chapter,we mainly developed a tandem cyclization borylation strategy using N-allyl-2-bromo-2,2-difluoro-N-phenylacetamide as substrate,and B₂pin₂ as boron source.A series of 4-boronate ester substituted difluoro-?-lactams were constructed.We explored the reaction mechanism and proposed a possible reaction mechanism.The reaction has a short reaction time,mild conditions,and is easy to operate.The synthesized borylated difluoro-?-lactams were easy to convert into various functional groups substituted fluorinated?-lactams,which have great value in the synthesis.In the third chapter,we initially explored the copper-catalyzed borylation/arylthiolation of alkenes for preparation of the borylated thioether compounds.