Preparation And Properties Of Electrospun PGS/SF Composite Medical Tubular Materials

Biomaterials are essential for the construction of tissue engineering artificial blood vessels.Biodegradable elastomers have similar properties to soft tissues,and are a very important type of biological material used to diagnose,repair or replace soft tissues in the body,such as blood vessels,urinary tubes,trachea,tendons,ligaments,etc.Small-calier artificial blood vessels do not match the compliance of the host blood vessels after transplantation,resulting in problems such as thrombosis and intimal hyperplasia,which leading to transplantation failure.Since the compliance of small-caliber artificial blood vessels is directly related to the elasticity of the preparation materials,it is necessary to find a suitable bioelastomer to construct small-caliber artificial blood vessels.In this work,the application of polyglyceryl sebacate(PGS)in artificial blood vessels is deeply studied.PGS is a class of bioelastomers with elasticity,biocompatibility,and degradability.The synthesis process of PGS is simple,and the mechanical properties of PGS can be adjusted during the synthesis process.PGS and natural polymer silk fibroin(SF)were used to fabricate small-caliber artificial blood vessels by electrospinging.Firstly,the morphology and structure of small-caliber artificial blood vessels were studied.Then,the tensile properties,elasticity,suture retention strength,and compliance were studied.In addition,its in vitro degradation and biological properties were also studied.Results showed that the morphology and structure of small-caliber artificial blood vessels are influenced by the concentration of spinning solution,PGS/SF ratio and curing conditions.When the curing temperature is 130? and the curing time is 24 h,the small-caliber artificial blood vessel has good elasticity and mechanical properties,its breaking strength,suture retention strength,and compliance are comparable with natural blood vessels.And with the increase of the proportion of PGS,the comprehensive performance has improved.In vitro degradation experiments showed that the addition of PGS accelerated the degradation rate of small-caliber artificial blood vessels.Cell experiments showed that the small-caliber vascular prosthesis prepared in this study can promote the adhesion and proliferation of human umbilical vein endothelial cells(HUVECs).In summary,the small-caliber artificial blood vessels prepared in this paper have potential application value in the field of tissue engineering artificial blood vessels.