Research Of Novel Hydrogel Sphericl Medium

Hydrogel is a type of hydrophilic polymer with a spatial network structure with biocompatibility and adjustable cross-linking degree.Hydrogels have played an important role in media carriers,drug delivery systems,tissue engineering,optics,diagnostics and imaging.This article focuses on the preparation of several new structures of hydrogel spherical microcarriers and their performance analysis,which provides new ideas for the preparation of functionalized media carriers.First,using agarose hydrogel as the matrix,a method of combining the three-stage suspension emulsification method and the solid porogen technology was designed to prepare a new type of multi-layer porous spherical medium.Method,a mixture of different porogen content and agarose concentration is prepared into spherical agarose gel microspheres in which the porosity inside the medium increases from outside to inside layer by layer,realizing the existence of pores on the same microsphere carrier The gradient is distributed layer by layer.The experimental results show that the method of combining the three-stage suspension emulsification method and the solid porogen technology in this study can prepare microcarriers with different levels of pore distribution.Among them,the best adsorption effect is the medium with decreasing porosity layer by layer from inner to outer A gradient multi-level pore distribution is conducive to the diffusion rate of molecules in the medium.Secondly,by mixing two different hydrogel materials,polyvinyl alcohol and chitosan,retaining their own characteristics,they are combined into a composite hydrogel spherical medium with a spatial interpenetrating network(IPN)structure.The experimental results show that the prepared microsphere carrier confirmed that the mixture of polyvinyl alcohol and chitosan hydrogel formed an IPN structure by FTIR,XRD or TGA analysis.When the amount of crosslinking agent was 1000 ?L,the microspheres had good sphericity.With BSA as the target protein,the adsorption capacity and adsorption rate of interpenetrating microcarriers are better than those of single hydrogel network microsphere media.Finally,the sodium alginate aqueous solution is mixed with the temperature-sensitive material PVME by a suspension method to prepare temperature-sensitive SA/PVME hydrogel microspheres.The mixture was characterized by FTIR and TGA;at normal temperature,the leakage rate of SA/PVME temperature-sensitive hydrogel microspheres PVME was large,while at 37?,the leakage rate of PVME was low,and its change rate remained basically within 4 hours.Unchanged;in addition,the temperature-sensitive carrier will be modified for in vitro drug release studies.As the PVME content increases,the encapsulation rate gradually decreases,but its temperature-sensitive response gradually becomes obvious.At present,this type of microcarrier has a high water content and should be New application fields can be developed.This thesis provides a new reference for the development of hydrogel microcarriers by developing several new hydrogel spherical media and characterizing their properties.