Study On The Preparation And Properties Of Molecularly Imprinted Polymers For Erythromycin

Erythromycin is a highly effective antibiotic.The remaining erythromycin can enter the body through the food chain,causing harm to human health.Therefore,non-toxic,low-cost,and easy-to-prepared materials are needed to treat residual erythromycin.In this thesis,by improving the preparation method,erythromycin molecularly imprinted polymers?ERY@MIP?were prepared.Based on this,magnetic erythromycin molecularly imprinted polymer?Fe₃O₄@ERY@MIP?was prepared using ferriferous oxide dioxide as carriers,the obtained Fe₃O₄@ERY@MIP are superparamagnetic and are convenient for rapid separation and recovery.Meanwhile,photodegradation of erythromycin molecularly imprinted polymers?TiO₂@ERY@MIP?were prepared using titanium dioxide as the carrier,the TiO₂@ERY@MIP easily photodegrade erythromycin.The preparation and main properties of these three molecularly imprinted polymers are as follows:?1?Preparation and Properties of Erythromycin Molecularly Imprinted Polymer?ERY@MIP?:erythromycin?ERY?,acetonitrile,acrylic acid?AA?,azodiisobutyronitrile?AIBN?and N,N-methylenebisacrylamide?MBA?were were mixed together to synthesize ERY@MIP by bulk polymerization method.And the ERY@MIP was characterized by thermogravimetry?TG?,Fourier transform infrared?FTIR?and scanning electron microscope?SEM?.Characterization and adsorption experiment results show that ERY@MIP has good stability.As the initial concentration of ERY increases,its equilibrium adsorption capacity gradually increases,and the maximum adsorption capacity is 1048.8 mg·g^-1.Scarchard analysis shows that ERY@MIP has two different binding sites for ERY adsorption at different concentrations.By comparing the adsorption of antibiotics such as streptomycin?STM?,azithromycin?AZI?,tilmicosin?TILM?and roxithromycin?ROX?by ERY@MIP,it was found that ERY@MIP had good selectivity and recognition for ERY.Reusability studies have shown that the adsorption efficiency of ERY@MIP for ERY reuse 5 times can still reach more than 60%.In the isothermal adsorption model,experimental results are most consistent with the Langmuir isothermal model.Kinetic studies show that the adsorption process conforms to the pseudo-second-order kinetic model.Thermodynamic studies show that the adsorption process is spontaneous,the amount of adsorption increases with increasing temperature,and the degree of chaos increases during the adsorption process.?2?Preparation and Properties of magnetic erythromycin molecularly imprinted polymer?Fe₃O₄@ERY@MIP?:Similar to the method for preparing ERY@MIP,the bulk polymerization method is still used in the preparation of the Fe₃O₄@ERY@MIP,only the magnetic Fe₃O₄ nanoparticles,which were synthesized by hydrothermal method,are added in the preparation of the ERY@MIP.SEM,FTIR,X-ray powder diffraction?XRD?,TG and hysteresis loop?MHL?characterization results and adsorption experimental studies show that Fe₃O₄@ERY@MIP has good thermal stability and has superparamagnetism.The maximum adsorption capacity for ERY is 958.38 mg·g^-1.Fe₃O₄@ERY@MIP has a better specific selectivity for ERY.The efficiency of five reuses can still reach more than 70%.Scarchard analysis shows that Fe₃O₄@ERY@MIP has high affinity and low affinity binding sites for ERY adsorption process.The isothermal models show that the adsorption process conforms to the Langmuir model and the pseudo-second-order kinetic model.Thermodynamic studies show that the adsorption process is a spontaneous,endothermic and entropy increasing.?3?Preparation and Properties of photodegradable erythromycin molecularly imprinted polymer?TiO₂@ERY@MIP?:similar to the preparation method of ERY@MIP,the carrier TiO₂ is added to the preparation process of ERY@MIP to obtain TiO₂@ERY@MIP.Characterization results of SEM,FTIR,XRD and TG and adsorption experiments on ERY show that the prepared TiO₂@ERY@MIP has high thermal stability and good adsorption performance.And show a certain photodegradation effect.Static adsorption experiments show that the maximum adsorption capacity of TiO₂@ERY@MIP for ERY was 1170.3 mg·g^-1.TiO₂@ERY@MIP had better specific selectivity for ERY.The efficiency of reusing five times can still reach more than 80%.The adsorption process conforms to the Langmuir isothermal model and the pseudo-first-order model which is a process of spontaneous entropy increase and endothermic.