Numerical Modeling And Structural Optimization Design Of Microspheres Prepared By High-Pressure Homogenizer

The high-pressure homogenizer is one of the more effective production equipment for preparing nano-and micron-level liquid products by adopting high-precision technology.This research is based on the Shandong Province Key R&D Program Project [2015GGX103022],and uses high-pressure homogeneous preparation of drug-loaded microspheres as the research object to achieve controlled production and technological innovation.During the high-pressure homogenization process,there are multiple phase interfaces coexisting,the physical and chemical phenomena are complex,the homogenization cavity is narrow,and the work is in a closed environment.The internal situation is difficult to detect by traditional means.In order to better understand the internal flow field distribution and achieve more efficient production control,with the development of computer technology,numerical simulation technology is gradually applied to homogeneous production.The numerical calculation method is expected to provide effective technology Information,solve the problems encountered in homogenization,and finally achieve the development and improvement of high-pressure homogenization technology.The establishment of the numerical model is an important guarantee for the controllable production of high-pressure homogeneous preparation of microspheres,and also an important way to achieve the optimization of homogeneous structure.Before the model is established,the experimental preparation process of microspheres is carried out to provide theoretical and experimental support for the modeling work.In order to improve the calculation accuracy,a homogeneous cavity watershed modeling was carried out.Choosing an unstructured grid,encrypting it at key locations,and optimizing the quality of the grid will help the grid and boundary of complex shapes such as bevels and radians to achieve a better fit.In the establishment of the numerical model,the k-ε model,Discrete Phase Model model,pressure-based solver,SIMPLE algorithm,and QUICK format that are more suitable for the homogenization process of microspheres were determined.The numerical model calculation results reflect the shear effect,impact effect and cavitation effect in the flow field.In order to ensure the accuracy of the model,the particle size statistical analysis of the multi-pressure gradient microspheres was carried out,and the verification and comparison of the simulation results were completed through the one-to-one corresponding high-pressure homogenization experiment.The results show that the numerical model and the experimental results are better The unity of the system achieves the desired effect of numerical simulation technology to guide the production of high-pressure homogeneous preparation microspheres.Based on the established reliability numerical model,based on the principle of energy conservation,the topological relationship was screened based on the speed,the optimized structure was selected,and the three structures of the homogeneous cavity corner spacing,corner radian,and corner taper were selected as the optimization scheme.Through the analysis of the experimental data of multiple groups of structures,it is confirmed that the data meets the equation fitting conditions,the ternary cubic relationship equations are fitted,and the validity of the equations is verified,and the continuity optimization of the relationship of multiple structures is achieved.The particle swarm optimization algorithm was used to obtain the optimal structural parameters,and the optimal structural model was established and verified by simulation calculation.After the structural optimization,the fluid velocity was increased by 26.9% under 30 MPa pressure,and the particle size reached the treatment effect of 50 MPa pressure.According to the principle of conservation of energy,other conditions are the same under the same pressure,the kinetic energy is significantly increased,and the work of heat production by overcoming friction is inevitably reduced.This not only solves the problem of high pressure and overheat damage products,but also can effectively save energy and achieve green and efficient production.