| Objective: Fluorine chemistry has been all fields of our life,fluorine-containing amino acids have important medical value and Method of synthesizing amino acids via catalysis of transition metal is efficient and mild.Therefore,we hope to achieve the efficient synthesis of fluorine-containing amino acid derivatives through the difunctionalization of olefin.Methods: This paper used N-vinylacetamide as raw material,[Ni] as catalysis.The difunctionalization reaction of olefin was carried out to synthesize fluorinated amino acid derivatives under more warm and efficient conditions.Result: We obtained the optimal reaction conditions by screening.A bifunctionalization reaction of N-vinylamide and its subsequent conversion reaction were achieved by using5,5’-ditrifluoromethyl-bipyridine as ligand under the catalysis of ditrifluoromethyl nickel.39 new compounds were successfully synthesized in moderate to good yield and determined by nuclearmagnetic resonance(NMR)and high resolution mass spectrometry(HRMS).Conclusion: This method has its advantages with mild reaction conditions and good substrate universality.The reaction also applies to internal olefins. |
