| Since the first report of palladium-catalyzed carbonylation organic reaction in 1974,the reaction has been rapidly developed and studied in industrial production and laboratory research.Carbon monoxide is an important source of C1,with the advantages of easy availability,cheap price.However,carbon monoxide is colorless and odorless.If the human body inhales directly,it will cause irreversible damage to them.At the same time,most of the currently reported alternative carbonyl sources will release some substances after releasing carbon monoxide.These substances may participate in side reactions or directly affect the yield of the reaction.Therefore,we are committed to developing some new alternative carbonyl sources.After the release of carbon monoxide,if the substances left behind can directly participate in the reaction or promote the reaction,the atomic utilization rate of the reaction will be improved.The main research contents of this paper are as follows:1.Develop a new type of aryl enol ester which provide CO and acetophenone.After iodobenzene participates in the reaction to form benzaldehyde,it forms chalcone with the acetophenone provided by aryl enol ester.The reaction is a tandem reaction with high yield and good substrate suitability2.Develop a new alternative carbonyl source benzyl formate,which can provide CO and benzyl alcohol.With the participation of bromobenzene,benzyl alcohol attacks as a nucleophilic reagent,the two things reacted and produce benzyl benzoate.The reaction has good substrate applicability and high yield,and is a good method for preparing benzyl benzoate.3.In this reaction,dimethyl carbonate has a triple role as a solvent,an activator for removing the CO bond of benzyl alcohol,and provides a source of methanol,so that benzyl formate can undergo a palladium-catalyzed carbonylation reaction in dimethyl carbonate.This reaction produces alkyl 2-arylacetate.The reaction yield is high and the substrate has good applicability. |
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