Regulation And Application Of Single Chiral Assemblies Of Amion Acids Derivatives

At present,supramolecular chirality is attracting more and more attention in the fields of chemistry,biomaterials and life sciences due to its unique performance and structure.How to understand and regulate the supramolecular chirality at the molecular level is a huge challenge.In order to reveal the puzzle,we synthesized a series of chiral materials for the study of supramolecular chiral materials.Amino acid materials have been widely used due to their high cost performance,multiple functional groups,stable properties and excellent chiral resolution and recognition ability.It is important to understand the process of supramolecular chiral assembly by studying the chiral assembly of amino acids.Through organic synthesis,this paper designed a series of chiral amino acid molecules,and by molecular self-assembly,through simple solvent,the preparation of the chiral screw assembly features good,stable nanometer material,through environmental scanning electron microscope,Fourier transform infrared spectrometer,CD spectra,XRD and other modern analysis instrument to study the solvent of rich electronic amino acid chiral compound self-assembly,amino acid in the process of forming supramolecular chiral molecules way of accumulation,clear the phenylalanine molecular self-assembly characteristics,and explores the amino acids material application of chiral recognition and chiral template.The research is as follows.In this paper,a series of electron-rich amino acid molecules were designed by organic synthesis.The effects of solvent on chiral self-assembly of LTP were studied,and the characteristics of self-assembly of LTP molecules were explained clearly.The chiral recognition of a series of charged chiral amines was studied by using the molecular assembly characteristics.The chiral template obtained by LTP self-assembly was used to study the synthesis methods and properties of noble metal chiral helical nanowires.(1)Regulation and Mechanism of L-phenylalanine Amino Acid Chiral AssemblyA series of chiral amino acid molecules were synthesized by organic synthesis method using phthaloyl chloride,trimesoyl chloride and L-amino acid methyl ester hydrochloride as raw materials,and Fourier transform infrared spectroscopy,nuclear magnetic resonance spectroscopy and mass spectrometry were used.Methods The structural amino acid molecules were characterized.Through simple solvent regulation,a single chiral assembly was controlled,and the material was characterized by SEM,CD spectroscopy,ultraviolet,etc.The results showed that the material structure was regular and had a regular spiral structure,in order to further study the formation of chiral assemblies.Mechanism and driving force,crystal analysis of it,LTP molecules in the self-assembly process through the hydrogen bond and π-π and other multiple forces synergistic effect,with four molecules as a unit cell,infinite grid-like accumulation,thus get spiral structurechiral(2)Recognition of l-phenylalanine amino acids chiral materialsBased on the above the screw material and reveal the molecular mechanism of spiral material formation,we know that the molecule in the process of self-assembly has multiple forces of synergy,assembling has obvious characteristic,so the molecules in between isomer,prone to markedly different degree of van der Waals force,hydrogen bond and other non covalent reaction.So we will be a series of chiral amine with charge induction type of molecular self-assembly,phenylalanine by uv and CD spectra,SEM,FT-IR,nuclear magnetic resonance hydrogen spectrum(1 HNMR)instruments such as the phenomenon and mechanism of chiral recognition,the results show that the driving force of the identification process is mainly hydrogen bonding interaction,because the isomers of space configuration is different,phenylalanine class chiral spiral material has specificity on r-mode chiral amine chiral recognition effect.(3)Application of L-phenylalanine amino acid chiral assembly in chiral templateIn this paper,we use the wet chemical chiral template method to pass the metal platinum nanometer through the phenylalanine molecular spiral nanomaterial as a chiral template to carry out the template synthesis method,and the materials are analyzed by environmental electron scanning electron microscope and energy spectrum.Characterization showed that the metal platinum chiral helical nanowires were initially synthesized.In order to further study the properties of the new materials formed,we characterized the properties of the materials by modern instruments such as CD spectroscopy,UV-Vis spectrophotometer,and fluorescence.New material CD signals were found to be enhanced,fluorescence increased,and new optical properties appeared.