Association Of PM_2.5 Personal Exposure With Blood Routine Indexes Among Two Cities' Adults And Children In Panel Studies

Objective:The evidence concerning the association between PM_2.5 and blood routine indexes was inconsistent and most studies were limited to middle-aged and old people,leaving lack of proof for the relationship of PM_2.5 and erythrocyte or platelet morphological parameters among children.Thus,we aimed to investigate the association between PM_2.5 personal exposure and blood routine indexes among adults and children.Methods:We performed three panel studies with three repeated visits in 143 adults and137 children from Wuhan and 145 children from Zhumadian in summer,autumn and winter,respectively.PM_2.5 personal exposure was monitored for 72 hours by MicroPEM personal monitor and the questionnaire was conducted before the physical examination.We used the linear mixed-effects model to evaluate the association between PM_2.5 personal exposure and blood routine indexes after excluding subjects with acute infection,loss of follow-up or missing covariates.Results:Among the adults in Wuhan,PM2.5 exposure was inversely associated with mean corpuscular volume?MCV?,mean corpuscular hemoglobin?MCH?,and mean corpuscular hemoglobin concentration?MCHC?.A 10?g/m³ increase in PM_2.5 personal exposure was associated with decreases of 0.16%in MCV,0.24%in MCH and 0.09%in MCHC at lags of 0-6 hours.All these associations were more obvious in women and subjects with passive smoking or daily exercise less than one hour averagely.Among the children in Wuhan,a 10?g/m³ increase in PM_2.5 conferred a 0.22%increase in red blood cell volume distribution width?RDW?within the lag 25-48 hours and this effect was more evident in boys,children aged 11-13y or with PM_2.5 personal exposure higher than the national secondary concentration limit?24h average concentration:75?g/m³?.The stratification results indicated that PM_2.5 has significant associations with mean platelet volume?MPV?,platelet distribution width?PDW?,platelet-large cell ratio?P-LCR?among boys and children with PM_2.5 personal exposure higher than 75?g/m³.Among the children in Zhumadian,an increase of 10?g/m³ in PM_2.5,the increment was 0.79%in white blood cell?WBC?,0.28%in mean platelet volume?MPV?at lags of7-24 hours.Lymphocyte?LYM?had an increment of 0.93%-0.94%in the first 24 hours after exposure while middle cell?MID?was also increased 1.23%-2.38%at lags of 0-48hours.The associations were more apparent in boy,children aged 4-8y and children with PM_2.5 personal exposure higher than 75?g/m³.Conclusions:Increased PM_2.5 personal exposure was significantly associated with multiple indexes of blood routine,but the effects varied across adults and children from two regions.