Synthesis And Biomedical Applications Of Nanomedicine Carriers

Nanoscience is an interdisciplinary subject based on a variety of advanced science and technology.As an advanced high-tech science and technology,nanotechnology has developed very rapidly in the past few decades with the development of characterization technology and measuring instruments.The nano-materials of nano-science and technology have great application value in biomedical field due to their special properties,such as small size effect and surface effect.It is one of the hotspots of scientific research.These include drug nanocarriers,medical imaging and cancer treatment.At present,cancer is a serious threat to human health.Among the many methods for treating cancer,traditional chemotherapy is one of the most common cancer treatment methods.However,chemotherapeutic drugs can cause systemic side effects and cause complications in patients with cancer cells.The reason is that chemical drugs are not specificity for cancer cells in the treatment of cancer,and are highly toxic to normal cells and tissues.Nano pharmaceutical carriers offer new ways to address the serious side effects of chemotherapy.Silica,liposome,various polymers,etc.can be used as drug carriers,and the targeted modified nanocarrier can accurately transport cancer drugs to tumor sites and effectively act on tumor cells,directly improving chemotherapy effect and improving treatment of drug-resistant cancer cells and reduce the toxicity of chemotherapy drugs to normal cells.Photothermal therapy is specific for inhibiting tumor tissue with few complications.In order to achieve synergistic effect of thermochemotherapy,multi-functional drug nanocarriers with good biocompatibility,biodegradability and high photothermal conversion efficiency have shown wider application prospects.This article will comprehensively expound the biomedical applications,synthesis,characterization and development direction of multifunctional nanomaterials.It mainly includes the following work content:(1)Preparation of polydopamine(PDA)-doped and folic acidmodified mesoporous silica(MSNs)nanoparticles(PMSNs)for targeting liver cancer cells by loading the anticancer drug doxorubicin(DOX),chemistry treatment and photothermal therapy work synergistically.The material was synthesized by using oil-water two-phase method based on the synthesis of MSNs.The preparation method was simple and convenient.At the same time,the controllable synthesis of PMSNs could be achieved by controlling the content of DA·HCl and the reaction time.The doping of PDA enhances the biodegradability and photothermal properties of PMSNs.Simultaneously,PMSNs showed good biocompatibility in in vitro cytotoxicity experiments.In addition,the material enhances the inhibitory effect on liver cancer cells in an in vitro anti-tumor experiment,indicating that its targeted therapy and thermochemotherapy synergistically.(2)Preparation of nanocomposites(rGO@PVMSNs).The material is synthesized by PDA-doped virus-like mesoporous silica nanoparticles(VMSNs)grown over and reduced the surface of graphene oxide.The presence of PDA shortens the synthesis time of virus-like silica and makes the preparation more time-saving.At the same time,both PDA and rGO have strong photothermal properties,and the drug doxorubicin(DOX)is loaded on the surface of rGO@PVMSNs for chemotherapy and photothermal therapy.In in vitro cell experiments,the material exhibited good biocompatibility and strong inhibitory effect on HepG2 cells,meanwhile in the in vivo animal experiment,the external laser light source irradiation and the in vivo drug action simultaneously inhibit the tumor growth,and significantly improve the therapeutic effect.