1,6-Conjugate Addition Of Para-quinone Methides With Acyl Radical And α-cyanation Of Amine Via Visible Light Photocatalysis

In recent years,visible light catalysis has rapidly developed into an important branch of organic synthesis due to its high atomic economy and in line with the current development of green chemistry,which has attracted the attention of scientists.The general mode of the visible light catalyzed reaction is that the organic conjugated macromolecular substance or the transition metal complex is photoexcited and undergoes a single electron transfer or energy transfer process with substrates to generate a key radical intermediate,and the radical intermediate further undergoes radical addition,Free radical coupling,free radical tandem and other processes are used to synthesize the expected products.This paper introduces the recent achievements of visible light catalysis,and based on the theoretical study of visible light catalysis,synthesizes important diaryl ketones and fats in natural products and drug molecules.a family of cyano compounds.Part I: this chapter introduces the early and recent work progress of visible light catalysis,and describes in detail how acyl free radicals are produced and their applications in organic synthesis.And a systematic summary of the photocatalytic reaction.Part I:In the second chapter,this chapter first introduces the synthesis methods of α,α-diaryl ketones and their applications in synthesis.Based on this and the knowledge of photocatalysis we have studied,we have designed and developed a photocatalysis acyl radical 1.6 addition reaction: Here we successfully synthesized the α,α-diaryl ketone compound using aryl keto acid as the acyl radical precursor and methylene benzoquinone as the free radical acceptor.Part I:In the third chapter,this chapter first introduces the synthesis of cyano compounds and the application of cyano compounds in organic synthesis.Taking this as the reaction background,we realized the direct cyanation reaction of carbon-hydrogen bond by double catalytic cycle mode: hydrogen atom transfer catalysis and photocatalysis.