Iron-catalyzed Cross-coupling Of Secondly Alkyl Chloride And The Alkynes Grignard Reagent

Palladium,Cobalt and their like can catalyze the cross-coupling reactions with high yield.However,this kind of catalyst are toxicity and expensive.These disadvantages limit them to be used in Organic Chemistry.Recent years,with the spreading of Green Chemistry,more and more researchers devoted themselves into exploring iron,which is cheap and green,to catalyze different kinds of coupling reactions.For example,someone has used Fe?acac?₃ to catalyze the coupling of the aromatic and the alkyl Grignard reagents.However,few scientists have researched the coupling between the alkyl chlorides and the alkynes,especially the secondary chloride alkyl halides for whose activity is worse than iodide alkyl halides and bromide alkyl halides.The amount and kinds of alkyl chlorides and alkynes are really abundant in the organic chemistry.So developing a green method to catalyze the coupling of secondary alkyl chlorides and the alkynes Grignard reagent is meaningful.In this article,we developed a green and simple method to catalyze the coupling of secondary alkyl halides and the alkynes Grignard reagents in the presence of Xantphos.And it has been successfully achieved in high yield using FeCl₃ as catalyst.Compared with the published methods,it used FeCl₃as catalyst to substitute palladium and nickel,which cut the cost and was in accord with the theories of Green Chemistry and sustainable development.It was also easy handled and base-free.It possesses practical potential and exhibits promising in industry.