Effect Of Ultrasound Modification On Mechanical And Biological Properties Of Bone Scaffolds

At present,the repair of bone defect caused by bone tuberculosis is a difficult problem in clinical medicine.Tissue engineering has opened up a new way to repair bone defect.The micro-structure,macro-surface morphology,material properties and processing technology of tissue engineering scaffolds will have a vital impact on the overall biological and mechanical properties.Ultrasound can produce thermal effect,mechanical effect,hole effect and so on.It can change the properties or state of materials.It is one of the methods to modify materials.In order to further improve the performance of tissue engineering scaffolds and improve the biological and mechanical properties of scaffolds,the effects of ultrasound modification on the properties of tissue engineering bone scaffolds were explored.Firstly,tissue engineering scaffolds were prepared and modified by ultrasound treatment.The effects of different time and power on the properties of scaffolds were investigated.The samples were characterized by SEM,XRD,FT-IR,mechanical and swelling equilibrium experiments.The results show that the surface morphology and micropore of the scaffolds treated with ultrasound time and power have been improved,and the more obvious the improvement is with the increase of time and power.In the micro-mesoporous structure,the mesoporous diameter of the scaffolds treated with ultrasound power has increased significantly,and the hydrophilicity of PVA in the scaffolds treated with ultrasound time and power has decreased significantly,and the mechanical properties of the scaffolds have also been improved.The energy and stability were obviously enhanced.Then,in order to study the effect of ultrasonic treatment on the performance of coaxial bracket,a series of technological improvements were made to greatly improve the preparation efficiency of coaxial bracket.Then coaxial bracket was processed by ultrasonic time and power.The coaxial bracket shell was analyzed by SEM and XRD,and the stability of coaxial bracket was analyzed by swelling balance rate experiment.The results showed that the coaxial bracket stability was improved by ultrasonic treatment.The crystallinity of coaxial bracket shell materials treated by power and time decreases,and the micro-mesoporous structure and connectivity are improved after ultrasonic time and power treatment.In addition,the swelling equilibrium rate of coaxial tissue engineering scaffolds decreased with the increase of ultrasound time and power,and the stability of coaxial tissue engineering scaffolds increased.Finally,coaxial drug-loaded scaffolds were prepared,and SBP was used as simulated body fluid to carry out degradation and drug-loaded sustained release experiments.The degradation and drug-loaded sustained release properties of coaxial drug-loaded scaffolds were preliminarily studied.The final results showed that the degradation rate of coaxial drug-loaded scaffolds decreased with the increase of ultrasound power and time after modification.In addition,after ultrasonic power and time treatment,the drug-loaded coaxial bracket will lose a certain amount of drug,and the detonation phenomenon will be improved.