Design And Synthesis Of Novel Responsive Surfactants

Surfactants as new drug delivery systems(DDSs),not only having good surface activity(such as oil solution,emulsion,micellar system and self emulsifying drug delivery system),but also can be self-assembled into nanoparticles to solve the shortcoming of other drug carriers,such as low solubility,the problem of high permeability,have been wildly used in the pharmaceutical industry.Responsive surfactants which has the stimuli-responsive properties,such as pH,enzyme or light,can be self-assembled into nanomedicine with targeting delivery and control-release properties,and are expected to improve anti-cancer effects.In this thesis,a series of responsive surfactants were designed,synthesized and characterized.This thesis is divided into two parts:In the first part,we designed and synthesized a polymerizable responsive surfactant,and characterized the stability and responsiveness of its the self-assembled nanoparticles and characterized the stability and release behavior of the particles encapsulated with Nile red.A series of responsive crosslinking agents were designed to cross-link the surfactants with polymerizable groups,so as to fabricated the responsive cross-linked nanoparticles.In the second part,we designed and synthesized a variety of responsive surfactants,including light,acid,and acid and enzyme dual responsive.Their structures were characterized and verified by ~1H NMR and FT-IR.