The Study On Thyroid Health And Its Influencing Factors Of Radiation Workers

Objective:The aim of this work was to assesse the influence of low dose ionizing radiation on thyroid health of radiation workers systematically by Meta analysis.In order to provide scientific basis for radiation protection of radiation workers,thyroid health status of radiation workers was investigated,the current status of thyroid function was analyzed,and the risk factors of thyroid nodules was explored.Methods:1.Relevant literature published in official publications from 1996 to 2018 was searched,the documents were selected carefully in PubMed,Embase,CNKI,WanFang,VIP,etc.by the pre-set inclusion and exclusion criteria,and the relevant data was extracted for analysis.The statistical software was Stata 14.0.2.A total of 1479 radioactive workers engaged in radioactive waste disposal,simple X-ray operation,isotope application and mixed irradiation were selected as research objects.Baseline data were collected through questionnaires;serum triiodothyronine(T3),thyroxine(T4)and thyroid stimulating hormone(TSH)were measured by chemiluminescence immunoassay,and the change of relevant indicators was observed.The color Doppler ultrasound diagnostic apparatus was used to detect the thyroid gland and find single and multiple nodules of the thyroid gland.After the data was collected and arranged,the database was built using Epidata 3.2 software.All the data were entered by the special person twice and the quality control measures were taken.The data was finally aggregated and analyzed using SAS 9.2 statistical software with a test level of 0.05.Results:1.Meta-analysis results show that the five sets of meta-analytical models all adopt random effects model.Meta-analysis of thyroid function in radiation workers was as follows.T3 levels were measured:SMD=-0.78,95%CI(-1.22,-0.33),P=0.03,which showed a reduced risk compared with the control group;T4 level test:SMD=-0.36,95%CI(-0.70,-0.03),P=0.04,there was a reduced risk compared with the control group;TSH level detection results:SMD=0.90,95%CI(0.26,1.53),P=0.006,there was an increased risk compared to the control group.Meta-analysis of thyroid nodules showed that the thyroid nodule detection rate of radiation workers:ES=0.23,95%CI(0.13,0.32),P=0.02,the difference was statistically significant;the thyroid nodules in the radiation group and the control group Detection:RR?1.34,95%CI(1.04,1.73),P=0.03,there was an increased risk of thyroid nodules compared with the control group.2.Serum detection analysis:T3 level results showed that there was statistical difference between the X-ray operation group and the other three groups,between different working years,between women and men,and between the annual effective dose<0.45mSv group and?0.45mSv group.Differences;T4 level results showed:comparison between four groups of different types of work,women and men,per capita annual effective dose<0.45mSv group and?0.45mSv group were statistically different;TSH level results showed:There were statistical differences between men and women,which was the same as working ages.3.Analysis of B-ultrasound results:The comparison of the detection rate of single thyroid nodules showed that the comparison between the radioactive waste treatment group and the isotope application group was compared between the different working ages,and the comparison between the female and the male and the per capita annual effective dose<0.45mSv group and?0.45mSv group.Statistical differences;the results of multiple thyroid nodules detection rate comparison showed that only between different working years,the difference between female and male was statistically significant.4.Risk analysis of thyroid nodules:Univariate and multivariate logistic regression analysis showed that the risk of thyroid nodules in other types of work was OR=1.584(95%CI:1.336-1.951,P<0.001)compared with X-ray irradiation workers;the risk of thyroid nodules in women was OR=1.658(95%CI:1.455?2.107,P=0.001);the risk of thyroid nodules increased with radiation age,age,and annual effective dose per capita,and their OR values(95%CI)are respectively 1.669(1.258?2.361),1.123(1.014?1.225)and 1.350(1.207?2.004).Conclusion:1.According to Meta-analysis,it is found that low-dose ionizing radiation could adversely affect the thyroid function of radiation workers,and the detection rate of thyroid nodules of radiation workers is higher than that of non-release workers.2.There were differences in the detection rates of thyroid function and thyroid nodules among radiation workers with different types of work,gender,length of service,and per capita annual effective dose3.Other radioactive work(except for X-ray operation alone),female,age?40 years,length of service?15 years,and annual effective dose per person?0.45 mSv may be used as independent risk factors to affect the occurrence of thyroid nodules.