The Chemical Synthesis And Properties Of Catalytic Ternary Chalcogenide

As the disease with the highest mortality rate in contemporary society,cancer is the primary factor which endangers the health of human.The side effects of traditional treatments have led researchers to develop new ways.Photodynamic therapy and chemodynamic therapy,which based on reactive oxygen species,are two new promising methods for cancer treatment.Because of their high efficiency and non-invasiveness,they get widely concern.And it will be a challenging work if we can combine the two and develop a new drug model,by selecting suitable photodynamic reagents and chemodynamic reagents and combining them.And it will give full play to reactive oxygen species.In this work,a ternary chalcogenide Zn_xCd_1-xS,which has good photocatalytic activity,was combined with the chemodynamic reagent as Fe₃O₄ to construct a"nanocatalytic drug".We have successfully prepared Fe₃O₄@Zn_xCd_1-xS core-shell nanostructure by using amorphous layer conversion strategy combined with hydrothermal method.In vitro,the degradation experiment of methylene blue was used to simulate the effects of photodynamic and chemodynamic therapy.It was proved that the system can cause a amount of reactive oxygen species under the irradiation at the tumor environment.Meanwhile,it has been proved that the yield of active oxygen species is mainly related to the thickness of the Zn_xCd_1-xS layer.The MTT experiment showed that the Fe₃O₄@Zn_xCd_1-xS core-shell structure has a good cell compatibility and in vitro tumor cell killing assay proved its ability to kill tumor cells effectively.In this work,we also adopt the basic principles of photodynamic therapy to the field of anti-bacterial.An one-step hydrothermal method,which using AA-[Zn?OH?₄]^2-microspheres as a template,was employed to synthesize composite of another ternary chalcogenide?In₂S₃-ZnIn₂S₄?which can be activated by external light.Similarly,we demonstrated the ability of photocatalytic anti-bacterial by in vitro degradation of methylene blue and molecular-probe-detection experiments.In addition,we also found the optimal loading of In₂S₃ to optimize the antibacterial properties of the composite structure.At last,we chose the E.coli as a bacterial model for photocatalytic antibacterial experiments.The results showed that In₂S₃-ZnIn₂S₄ is an excellent photocatalytic antibacterial agent.