Preparation Of HfO₂ Nanoparticles With DNA Origami As Template

DNA origami self-assembly technology has been a focus of extensive interest owing to its excellent characteristics such as site-specific bases,arbitrary shapes and biocompatibility.At present,researchers have been able to design and synthesize three-dimensional complex shapes.To assemble the super-large area of DNA origami and explore the new design rules is the direction of current research in the field of DNA origami assembly technology.More scientific researchers are committed to exploring its applications.Till now,the applications of DNA origami in monomolecular detection,bio-drug delivery,nano-optoelectronics have been deeply studied.To make DNA origami endure harsher environment,to achieve mass production of DNA origami in applications,and to maintain the homogeneity of nano-devices as templates or vectors are dilemmas in the application direction of DNA origami.This thesis focuses on the application of DNA origami in nanoelectronics,which is studied from the following two aspects.(1)DNA origami is studied on mica substrate on most conditions nowadays.Exploring the deposition conditions of DNA origami on other substrates is a necessary condition to expand the application of DNA origami.In this paper,the optimal deposition conditions of DNA origami on silicon and silica substrates are investigated,and the mechanism of DNA origami on substrate deposition is analyzed.And the DNA origami is successfully deposited on the electrically neutral surfaces,such as silicon substrate modified by Pt and silica substrate modified by HMDS self-assembled monolayer.Researching the deposition conditions of DNA origami is benetifical to the development and expansion of the potential application of DNA origami.(2)A preparation method of transferring DNA origami nano-shape to high k material is presented.DNA origami is combined with inert self-assembled monolayer with hysteresis effect on hafnium oxide atomic layer deposition(ALD),and the area-selective hafnium oxide ALD at low temperature is realized.Eventually,hafnium oxide nanoparticles with DNA origami shape are prepared,and these nanoparticles can be transferred from original substrates by DNA hydrolases.This method has the advantages of autonomous design of nanoparticle shape as well as controllable reaction,which has great potential application value in the field of nano-photoelectronics.