The Construction Of Nanomaterials Based On Pillar[5]arene And Applications In The Fields Of Biomedical Science And Optoelectronic Information

Self-assembly is an important process in which simple molecules form more complicated structures based on spontaneous interactions among themselves.Various supramolecular interactions offer great potential for the construction of non-covalent supramolecular nanomaterials with tunable properties and functions.After decades of research,supramolecular self-assembly strategies become promising methods which have greatly extended the scope of functional nanomaterials in the field of biomedical science,optoelectronic information technology and environmental science.Herein,water-soluble pillar[5]arene is used as the macrocyclic host molecule and size-suitable small molecules are designed as functional guests.Consequently,based on the host-guest interactions,two kinds of naonomaterials can be achieved successfully,which have outstanding abilities in diabetes diagnosis and treatment and fluorescence regulation,indicating their great potential in the fields of biomedical sciences and photoelectric information technology.The main research contents include the following two aspects:In the first part,supramolecular theranostic nanoplatform based on pillar[5]arene and diphenylboronic acid derivatives for integrated glucose sensing and insulin delivery is constructed.In this system,water-soluble pillar[5]arene(WP5)is used as the host molecule to form a supramolecular amphiphile(WP5(?)G)which can further assemble to form vesicles with the bisphenylboronic acid derivative(G)as the guest molecule.With the insulin and glucose oxidase encapsulated inside,the obtained insulin-GOx-loaded supramolecular vesicles can selectively recognize glucose.In hyperglycemic conditions,vesicles disaggregate and the entrapped insulin is released to regulate blood glucose levels.Whereas,very limited insulin is released under normal blood glucose environments.Moreover,the insulin release process can be easily detected by naked eye through monitoring the excimer-monomer conversion of the guest.In vivo experiments further demonstrate that this kind of smart supramolecular nanocarrier shows fast response to hyperglycemic circumstances and can effectively regulate the glucose levels in a mouse model of type I diabetes.Therefore,it may have great potential in the field of biomedical science.In the second part,based on the host-guest interaction between water-soluble pillar[5]arene and conjugated polymers,three kinds of fluorescent nanoparticles are constructed,which exhibit red,green,and blue color,respectively.The fluorescence can be quenched or reversibly recovered by Fe3+/EDTA or UV/Vis.Moreover,by introducing CPPO moiety as an energy donor,efficient chemiluminescence can be observed by the naked eye under the stimulation of H2O2.Notably,tunable fluorescence and white light emission can be achieved by altering the proportion of the three primary color nanoparticles.In summary,a novel kind of fluorescence tunable nanomaterials are constructed based on the supramolecular strategies,which provide new ideas for the application of functional nanomaterials in the field of anti-counterfeiting ink.In conclusion,two kinds of naonomaterials with the function of diabetes diagnosis and treatment and fluorescence regulation are constructed respectively based on the supramolecular strategies,which are expected to provide the potential applications in the fields of biomedical science and optoelectronic information technology.