Study On The Synthesis Of Vicinal Diamine Analogues Via Visible Light Photoredox Catalysis

On the basis of our previous research on the radical-based methodologies for construction of α-Bmino carbon-carbon bonds,the study of the synthesis of vicinal diamine analogues via visible light photoredox catalysis have been conducted.The main results are exhibited in the thesis and listed as follows:1.The Cross-Coupling of Nitrones with Arylamines via Visible Light Photoredox CatalysisVicinal diamines are important motifs found in many bioactive alkaloids and medicinal agents.Moreover,they could serve as chiral auxiliaries,ligands and organocatalysts,thus paly an important role in asymmetric synthesis.As a readily available nitrogen source,nitrones have been used in many reactions to prepare nitrogen-containing organic compouds.Inspired by the previous research,a cross-coupling reaction of nitrones with arylamines via visible light-excited photoredox catalysis has been developed without the use of additional stoichiometric co-oxidant or co-reductant,and a series of a-amino hydroxylamines have been prepared.This method features by mild conditions,simple operation,atomic economy and a broad scope of nitrone substrates.2.The Cross-Coupling of Carbamates with α-Ogime Exters via Visible Light Photoredox Catalysisα,β-Diamino acids have unique structure and can be found in many bioactive natural products and medicinal agents.In this thesis,a cross-coupling reaction of carbamate with a-oxime exters via a dual of photoredox/lewis acid catalysis has been explored,through which α,β-diamino acid derivatives have been prepared.Futhermore,the preliminary study of enantioselective catalysis of this reaction has been conducted.