| As the second generation body compounds of supramolecular chemistry with unique structure,excellent physiochemical and specific targeting characteristics,cyclodextrins were developed rapidly in recent years.Conjugates and polymers based on cyclodextrins was one of the most important filed of cyclodextrin chemistry.In order to inside the preparation methods and the properties of conjugates and polymers based on cyclodextrins,we synthesized a series of ?-cyclodextrin derivatives and conjugated antitumor drug 5-fluorouracil to these ?-cyclodextrin derivatives.In the other hand,we synthesized a?-cyclodextrin polymer with a novel route.These conjugates and polymers were further characterized by NMR,MS,XRD,TG,DSC,Fluorospectro photometer.This dissertation was mainly constituted of three sections as follows:1.Four cyclodextrin derivatives were selected and synthesized:mono(6-amino-6-deoxy)-?-cyclodextrin(NH2-?-CD),mono(6-ethylenediamino-6-deoxy)-?-cyclodextrin(EN-?-CD),mono(6-diethylenetriamino-6-deoxy)-?-cyclodextrin(Dien-?-CD),mono(6-triethylenetetraamino-6-deoxy)-?-cyclodextrin(Trien-?-CD).In the meantime,their structures were charactered by 1H NMR.2.Four 5-fluorouracil-cyclodextrin conjugates were synthesized:mono(6-(5-fluorouracil)-amino-6-deoxy)-?-cyclodextrin(5-FUA-NH2-?-CD),mono(6-(5-fluorouracil)-ethylenediamino-6-deoxy)-?-cyclodextrin(5-FUA-EN-?-CD),mono(6-(5-fluorouracil)-diethylenetriamino-6-deoxy)-?-cyclodextrin(5-FUA-Dien-?-CD),mono(6-(5-fluorouracil)-triethylenetetraamino-6-deoxy)-?-cyclodextrin(5-FUA-Trien-?-CD).In the meantime,their structures were charactered by 1H NMR and MS.These conjugates were further characterized by NMR,MS,XRD,TG,DSC.3.Three ?-cyclodextrin polymers were synthesized:Ethylenediamino/?-cyclodextrin polymer(P-EN-CD),Diethylenetriamino/?-cyclodextrin polymer(P-Dien-CD),Triethylenetetraamino/?-cyclodextrin polymer(P-Trien-CD),In the meantime,their structures were charactered by 1H NMR.These polymers were further characterized by XRD,TG and DSC. |
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