The Synthesis Of Sulfoxides (Sulfones) And (E)-?-Iodovinyl Sulfones

Sulfoxide?sulfone?derivatives have a wide range of biological activities,which have been widely used as a bacteriostatic agent,insecticides and antineoplastic drugs in the field of pesticides and medicine.It has been extensively reported about its synthetic methods,biological activity and mechanism studies.This thesis is consists of two parts.The first chapter presents an overview of sulfoxide and synthetic methods.A rapid and efficient method for the selective oxidation of sulfides through t-butylhydroperoxide?TBHP?in CHCl₃ at 60^oC has developed.There are20 different substratesbe investigatingto get the corresponding products,the yields were 67-98%.Compared with other methods,ithas the advantages of catalyst-free,easy operation,high selectivity,wide application and environmental benign.The second chapter briefly summarized?E?-?-iodovinyl sulfones and its synthesis methods.An efficient and convenient approach for the construction of various?E?-?-iodovinyl sulfones has been developed,via tetrabutylammonium iodide?TBAI?/potassium persulfate?K₂S₂O₈?facilitated reaction of sulfonylhydrazides with alkynes in CH₃CN at 80^oC.There are 12different substrates be investigating to get the corresponding products,the yields were 70-95%.The salient features of this reaction are the application of a new iodine source,good stereoselectivity,environmentally benign,safe solid oxidant and short reaction time.