Study On The Preparation And The Quality Control Of Baoqian Granules

Objective:Study on the Preparation and the Quality Control of Baoqian Granules,thus provide experience basis of preparation technology and quality control for prostatitis.Methods:prescription analysis and retrieval line screening to determine the extraction process routes,by using single factor test and orthogonal test,the extraction technology was optimized with the extracting ratio and the content of loganin,ferulic acid and naphtha inclusion rate as index;through comparing experiment the process of purification and concentration drying was made with the content of loganin,ferulic acid as index;the combination of granulation process and compression parameters gifted Baoqian Granules best molding process conditions;done by TLC Identification;using High Performance Liquid Chromatography(HPLC)determination,and methods of inspection.Results:Water extraction The optimum conditions:1.0 hours soaking water,extrating two times,and the water was eight times the medicine,six times,theextraction time of 2.0 hours,1.5 hours.preparation of inclusion.The optimum conditions:?-cyclodextrins:volatile oil(g:ml)=8:l,the temperature was 50 C,stirring time of 3 hours.Mention condensed water from liquid to a relative density of 1.08,alcohol precipitation,filtration,.and filter liquor spray drying at 190?.Process condition:drug powder:dextrin=13:5,95%ethanol solution+3%PVP for wetting agent.There was no negative interfernce with TLC of Alisma orientalis,Achyranthes bidentata,Radix Paeoniae,lumbricus,Radix Aucklandiae and cinnamon.The determination method of loganin,ferulic acid was feasible and repeatabe.Conclusion:The preparation technology is viable,And the quality control is reliable.It can be used to provide the basis for industrial production.