Research On MOF Derived Mesoporous Carbon Releasing Poorly Water-soluble Drug INC And Catalyzing Water Electrolysis

Biopharmaceutics classification system ??BCS ??drugs normally has low solubility in water,resulting in low oral bioavailability,which significantly limits its clinical application.In recent years,the appearance of a new type of mesoporous carbon nanomaterials can mitigate the above issues.Mesoporous carbon materials with the rich channels,high specific surface area,as a poorly soluble drug carrier,can effectively reduce crystallinity and improve dispersity of drugs,enhance the solubility of poorly soluble drugs.Therefore,they possess great potential as drug delivery systems.Hydrogen energy is a renewable energy source with high energy density,abundant reserves and negeligible pollution.It shows unique advantages in the field of new energy application and is the perfect substitution for fossil fuel.Although it is of great promises,the efficiency of currently industrial hydrogen production is quite low,which not only consumes the fossil fuel intensively,but also causes the emission of greenhouse gas carbon dioxide.Therefore,it is urgent to develop a cleaner,sustainable and more efficient strategy to prepare hydrogen.Water electrolysis is considered to be the most promising technology for hydrogen production.Therefore,it is a key problem to develop an efficient catalyst and improve the efficiency of electrolysis water.Using metal organic frameworks ZIF-67 as the precursor,a one-step pyrolysis method was developed to prepare the mesoporous carbon nanomaterials with uniform morphology,uniform size and rich pore channels.A variety of techniuqes including,scanning electron microscope,transmission electron microscope,X-ray diffraction,etc.were employed to characterize the morphology,structure and composition.The mesoporous carbon materials were used as drug carrier and electrochemical catalyst,respectively and their performances were systematically studied.The mesoporous carbon materials were used for adsorbing poorly soluble drug indomethacin through the drug release test and cell toxicity test to determine the amount of drug loading and dissolution release rate,respectively;By loading precious metal iridium,as electrochemical catalyst,the electrocatalytic performances toward both hydrogen evolution reaction and oxygen evolution reaction have been evaluated.And the overall water splitting catalyzed by the as-prepared materials was explored and visually observed.The main contents of this thesis include the following parts:1.Preliminary research on mesoporous carbon derived from metal organic frameworks ZIF-67 for loading indomethacin and catalyzing water splitting.ZIF-67 was synthesized with cobalt nitrate and 2-methyl imidazole as starting materials at room temperature.Then they were calcinated at different temperature and a series of mesoporous carbon doped nitrogen containing cobalt particles?Co-NC-x,x represents temperature?was prepared.Through a series of tests,the catalytic performances of Co-NC-x toward oxygen evolution and hydrogen evolution were evaluated.And the capability of dissolution and release of indomethacin were investigated as well.The results show that Co-NC-x can be employed as a drug carrier to adsorb indomethacin and the loading amount can reach to 20%,as well as the certain performance for catalyzing hydrogen evolution reaction and oxygen evolution reaction.2.Studies on adsorption and release indomethacin properties of mesoporous carbon derived from bimetal organic frameworks.Bimetal Zn_xCo_y-ZIF?x,y represents the percentage proportion of zinc and Co?was synthesized by adjusting the stoichiometry of zinc and cobalt.Then Zn_xCo_y-NC was prepared by calcinating Zn_xCo_y-ZIF at 900 ?.The effects of different ratios of zinc and cobalt on the morphology and specific surface area of carbon materials were analyzed through multiple characterization techniques.The amount of loading and rate of release of indomethacin rate of series of samples were observed.The results showed that amount of drug loading can reach to 31%.The dissolution tests demonstrated that the materials can significantly increase the solubility of poorly soluble drugs and its release rate.The results of magnetic measurement suggested that the samples possessed paramagnetism.Cytotoxicity tests demonstrated that the sample was of no significant toxicity to L929 cells within the range of 0.1?1000 g/mL,indicating that the material possessed excellent biocompatibility.3.Preparation and application in catalyzing total water splitting of mesoporous carbon derived from metal organic frameworks.Co/NC was synthesized at 900 ? by calcination of ZIF-67.Co@Ir-NC-x?x represents the percentage of Ir?with core-shell structure was prepared by Galvanic replacement reaction between iridium?Ir?salt and Co/NC.The performance of catalyzing OER,HER and water splitting of Co@Ir/NC-x series samples was examined.The results showed that Co@Ir/NC-10%possessed the best catalytic performance in the Co@Ir/NC-x series.For OER,the overpotential at current density of 10 mA cm^-2 was 280 mV,which is superior than the benchmark IrO₂ catalyst;For HER,to afford the current density of 10 mA cm^-2,the overpotential was-121 mV,which is close to the commercial Pt/C catalyst.In addition,OER stability is significantly higer than IrO₂,and HER stability is superior to Pt/C.Finally,the overall water splitting catalyzed by the materials was explored and visually observed.