Construction Of Fluorescent Probes Based On Tetrastyryl And Rhodol Derivatives And Their Sensing Effect On Mustard Gas

Mustard gas is a liquid poison that emits harmful gases and is a erosive agent in chemical weapons.From World War I to World War II,it was repeatedly used on a large scale,causing heavy casualties.There have been many incidents of mustard gas poisoning that have occurred in Japan after the Japanese invasion of China.At present,the methods for detecting mustard gas mainly include color-to-mass inline method,infrared spectroscopy,and chromatography.These traditional detection methods have their own advantages,but the drawbacks are extremely obvious,and false positives and false positives often occur.Under normal circumstances,the concentration of mustard gas poisoning is relatively low.How to obtain detectable mustard gas markers through appropriate sample pretreatment methods and select suitable detection techniques to improve the sensitivity of the method makes it very important to apply to practical poisoning sample detection research.significance.The fluorescence analysis method has the advantages of high sensitivity,high selectivity,non-invasive sample preparation,fast real-time in-situ detection,multi-signal output mode,etc.Therefore,the fluorescent probe is considered as one of the important tools for detecting and studying the sensing process.It has been widely used in the detection and analysis of bioactive molecules,anions and cations,and nerve agents.In this dissertation,a series of fluorescent probe molecules were designed and synthesized based on the tetra-styrene fluorescent chromophores with AIE properties and the “Rhodol-HBT” fluorescent dye with aggregation-induced release enhancement.The mustard gas was achieved in air,solution and soil.Sensitive applications of nerve agents such as mustard gas.The main research content of this paper is as follows:1.Based on the reaction of benzene methyl mercaptan with the analyte,fluorescent probes were developed for the detection of SM and SM mimetics(2-chloroethyl ethyl sulfide,CEES).A non-emissive fluorenylmethylphenyl-modified tetrastyrene(TPE)probe was designed and synthesized.In the presence of metal ions,after reacting with CEES in aqueous solution for 5 minutes,the probe emits a strong fluorescence due to the formation of a sandwich complex,which effectively limits the rotation of the TPE benzene ring.In addition,the program shows a high degree of sensitivity to analytes and can be used to detect CEES in soil.2.A spirocyclic ring-opened mustard gas of rhodamine-thioamide derivatives in the presence of mustard gas was developed based on a series of S-alkylation and desulfurization reactions in combination with a xanthene-based Rhodol dye and an HBT dye with ESIPT characteristics.The intuitive and highly fluorescent detection method.The analysis of its photophysical properties and single crystal structure shows that the fluorescence enhancement of this compound in aggregates can be restricted by the intermolecular rotation and vibration and the π-π stacking between the molecules existing on the different sides of the spirocycle.The synergistic effect of the ESIPT process caused by hydrogen bonding interactions is explained.The probes have no false positive interference with the SM,alkyl bromide,alkyl iodide and other oxygen analogues.Therefore,chemical dosimeters can be successfully used to detect SM in solution and gas phase.In addition,the program shows a high degree of sensitivity to analytes and can be used to detect CEES in soil.The sensitivity of the test is sufficient to detect sulfur mustard in the gas phase with the naked eye at ambient temperature,indicating that it has the potential to detect sulfur mustard on the spot with the naked eye.