Fluorescent Sensing Of Metabolism Biomarkers By Metal-Organic Polyhedron

Metal organic complexes,one of the most active areas in supramolecular chemistry,are not only a communication bridge of organic and inorganic supramolecular research but also penetrating into materials chemistry,bioscience,environmental science and other subjects.Due to its own nanoscale space which could accommodate small moluculars with appropriate size and limit spaces,metal-organic polyhedron built by self-assemble of metal ions and organic ligands facilitating interaction between host and guest developed rapidly.In the field of bioscience,the identification of biomolecular biomarkers is very important,which is conducive to the early,rapid and accurate diagnosis of diseases and provides the evidences for clinical treatment.Fluorescence method is a fast,high sensitive and low intrusive way to identify small molecular biomarkers.The chemists designed various types of fluorescent sensors,including organic fluorophore,quantum dots and rare earth luminescent complexes.The metal organic polyhedron could be utilized fluorescent sensor for identifing disease related small molecular biomarkers,and has the advantages of stable structure,high selectivity and good biocompatibility.Triphenylamine based metal organic tetrahedron Ce-TTS with blue fluorescent emission could be able to selectively encapsulate 5-HIAA and release the fluorescence signal through hydrogen bonding interaction,π-π stacking effect and spatial stereoselectivity.The fluorescence intensity of tetrahedron reaches a 2.6-fold increase upon addition of 5-HIAA and could quantitatively detect 5-HIAA in a wide range.Dihydropyridine based metal organic tetrahedron Ce-ZPS with redox activity could identify 4-ADNT molecules.With irridation by UV-light,the redox process between tetrahedron and guest moleculars could be induced,and encapsulate 4-ADNT with its proper confined cavity causing the fluorescent response of metal organic tetrahedron towards guest molecular.