Synthesis Of 9,10-Distyrylanthrance Deravitaves And Its Fluorescence Bio-Imaging Property

Recently,the luminescence materials have attracted more and more attentions.Compared with the traditional luminescent molecules,the aggregation-induced emission(AIE)molecules show significantly enhanced fluorescence emission because of its unique molecular structure and aggregated state.Taking advantage of these properties,the aggregation-induced emission molecules have been broadly applied in many areas such as photoelectric devices,biological probes and fluorescence bio-imaging.Moreover,it is a feasible method of using AIE effect to solve the aggregation-caused quenching(ACQ)phenomenon.Due to its simple structure,convenient synthesis and excellent performance,9,10-distyrylstilbene(DSA)with AIE properties has attracted the attention of researchers.In this thesis,9,10-distyrylanthrance(DSA)molecule,as an AIE-active material has been modified by introducing pyridine groups.Two different compounds including a pyridine(unsymmetrical SPyDSA)and two para pyridine(symmetric DPyDSA)has been synthesized respectively.The effects of concentration on the AIE performance of SPyDSA and DPyDSA have been investigated in detail.The mechanism of AIE phenomenon has been discussed from the following aspects such as intramolecular rotation restriction,intramolecular coplanar and the formation of special cream base associated content,etc.To further value its feasibility of bio-imaging,two kind of AIE nanoparticles have been prepared individually by its self-assembly,and their bio-imaging effects have been confirmed by MTT and fluorescence confocal in vitro.Studies on the structure of the pyridyl-modified DSA in the field of bio-imaging have not been reported.