Study On The Scald Preparation Of Chinese Medicine

Purpose: In this paper,the optimum extraction and preparation process is optimized by selecting and optimizing the composition of the group.In the dosage form,the optimum formulation and preparation process of microemulsion gel are optimized and the qualified preparation is prepared.Establish its quality standard,investigate its initial stability,and conduct a comprehensive study of quality control methods and standards.Method: The experiment uses uniform design to determine the composition of the group,and uses a scientific and feasible extraction method according to the difference of the properties of the effective components,that is,ethanol reflux extraction of alcohol soluble components and steam distillation to extract the volatile oil components,and the UV and HPLC analysis methods are established to determine the main formulation.The optimum extraction conditions were determined by the response surface method.The microemulsion was prepared by phase transfer emulsification and the pseudo three element phase diagram was used to optimize the prescription.The transdermal absorption capacity of the preparation was measured in vitro.TLC and high performance liquid chromatography were used to establish the quality standard and quality control,and the fine research system was made.The experimental conditions and important links of the agent process.Result: 1.Using the uniform design method and SPSS statistical data,the prescription and prescription selected by the group are determined as: Rhizoma Coptidis 20 g,cortex Phellodendron 25 g,Scutellaria 20 g,elm 10 g,borneol 10 g,myrrh 15 g.2.The best experimental conditions for the extraction of all kinds of effective components are that alcohol soluble effective components are reflued by reflux extraction with ethanol.The best extraction scheme is two times,2.5 h each time using 10 times the amount of 70% ethanol,and the best solution for extracting volatile components from steam distillation is to extract 4 h with 10 times of water.3.The best microemulsion formulations are as follows: oil phase IPM,surfactant Twain 80,surfactant free ethanol,Km value 3:1,oil phase and mixed surfactant ratio 4:6,triethanolamine as stabilizer,Carbomer as gel matrix,and two methyl sulfoxide as a permeation agent to prepare microemulsion gel Transdermal test showed that the skin permeability of the preparation was much higher than that of the ordinary ointment.Conclusion: In this paper,the proportion of the components is determined by the uniform design.Through the establishment of the methodology,the accurate and stable detection means are found.The optimum extraction process and preparation process are found through the process optimization.The quality and content of the preparation are verified by the quality standard.All the test and inspection results are in line with the latest 2015 edition.The relevant requirements of the Chinese Pharmacopoeia.