| In this paper,two series of branched block copolymer were designed and synthesized.The polymers were full characterized and respectively,their applications on biological field were studied.The details are as follow.1.In this part,AB slightly crosslinked branched diblock copolymers PEG-b-PNIPAm was synthesized by traditional radical polymerization.The polymer was employed to prevent drug crystallization during solvent evaporation and to stabilize the drug nanoparticles once suspended in aqueous media.After the initial solvent evaporation the dry materials obtained exhibit excellent stability during storage and can be readily dissolved in water to produce aqueous drug nanoparticles suspensions.Among the hydrophobic compounds investigated,Ketoprofen nanoparticles(Dh?200nm,stable up to 9 months in solution)can be produced with a drug suspension yield of 96%at a drug:polymer ratio of 0.33:1.UV-Vis spectroscopy has been used to determine the yield of drug suspended in aqueous media while cryo-TEM,dynamic light scattering(DLS)and powder x-ray diffraction(PXRD)are used to characterize the drug nanoparticles prepared.2.In this part,an linear ABA triblock copolymer(P(nBA-co-NIPAm)-b-PEG-b-P(nBA-co-NIPAm))was prepared by atom transfer radical polymerization.Then thermo-sensitive polymer/silver-containing graphene composite material(Hydrogel@rGO-Ag)was prepared by simple physical blending.The ideal gelation concentration was found to be 25 wt%.From rheological measurements,the sol-gel transition temperature was found to be 28?.Meanwhile,the thermo-sensitive composites gel material showed effective antimicrobial activities towards Escherichia coli(E.coli)and methicillin-resistant staphylococcus aureus(MASA),demonstrating the ability of protecting wound from pathogenic microbial infections.Furthemore,in vivo experiments on rats suggested the effect of in promoting the recovery of wound sites.In addition,the composite material own good biocompatibility,biosafety and great clinical potential. |
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