Tumor Theranostics Of Transition Metal Ions Loaded Polyaminopyrrole Nanoparticles

Tumor theranostics is a vitally significant application for nano-medical science.Plenty of nanoplatformsare tested as novel agents for tumor diagnosis and combination therapies.Some transitional metal ions also show good photothermal properties for photothermal therapy and as contrast agents for magnetic resonance imaging（MRI）.MRI is a precise and free of radiation imaging technique for the diagnosis of soft tissue lesion.In addition,some of the transitional metal ions also carry certain dosage of toxicity,and can be used as chemotherapeutic drugs for tumor treatment.Particularly,there are two aspects described in detail in the following paragraphs.In chapter Ⅱ,polyaminopyrrole nanoparticles（PPy-NH₂ NPs）are prepared.It has high near-infrared absorption and good biocompatibility.,showing the potentials as photothermal therapeutic materials.Cu（Ⅱ）can be loaded in PPy-NH₂ NPs.Therefore,the prepared NPs are defined as Cu PPy-NH₂ NPs.Cu can be released under control in the organism,leading to the effect of chemotherapy and enhanced the effect of the therapeutic effect.Experimental results indicate that CuPPy-NH₂ NPs have good light stability,photothermal stability,biocompatibility and low toxicity.The optimal size of theranostic CuPPy-NH₂ NPs is 50.2 nm,which present a photothermal transduction efficiency of 76.4%.In chapter Ⅲ,because of the unpaired electron in Cu atomic orbits,CuPPy-NH₂NPs also show T₁-weighted magnetic resonance imaging.It can also significantly enhance the MRI function of the lesions.After thermochemotherapy,a complete ablation of human oral epithelial carcinoma tumors is observed.No tumor recurrence is found.This kind of transition metal-doped polymer gives a competitive approach for designing and fabricating multimodal theranostic nanodevices,which shows the new method in tumor treatment.