Transition Metal-catalyzed The Synthesis Of 2-arylseleno-benzothiazole&Benzimidazole And ?-chlorination Of 2-pyridine Arylether

This thesis is divided into four chapters.In the first chapter,recent advances in the transition metal-catalyzed synthesis of organoselenium compounds,?-C functionalization of aromatic compounds with a directing group are reviewed.In the second chapter,Copper-catalyzed three-component tandem reaction of benzothiazole&benzimidazole,iodobenzene,and selenium powder.A new route with excellent regioselectivity,broad substrate scope and compatible with various functional group for 2-arylseleno benzothiazole&benzimidazole has been developed which can avoid prepare phenylselenation reagent.It's also can produce more complex containing selenium compounds.And preliminary mechanistic experiments are investigated.In the third chapter,Palladium-catalyzed ?-chlorination of 2-pyridine arylether: An convenient,speedy and efficient method for synthesis of multisubstituted 2-pyridine choroarylether compounds using normal ethyl acetate as solvent has been developed,which can make the sequential 2-pyridine arylether derivatives and late-stage chlorination of bioactive compounds.Finally,preliminary mechanistic experiments are investigated.In the four chapter,experimental section including the experimental procedures,synthesis and structure characterization of starting materials and lisoquinoline derivatives are described.