Palladium Catalyzed Allyl Amination Of Cinnamyl Carbonate Compounds

Alylamine is an important basic skeleton in organic synthesis and is widely used in natural drugs,drugs and materials.Alyl amine compounds with important biological activities are widely used in medicine,biology and so on.Moreover alyl amine compounds are also an important class of organic synthetic intermediates,and can be used in the synthesis of Nheterocyclic compounds,amino acids,alyl primary amines and other compounds.Therefore,it is of great significance to establish a highly efficient routine for the synthesis of allyl amine compounds.The alyl amination of cinnamyl methyl carbonate compounds and acyl hydrazone compounds catalyzed by palladium was studied in this paper.First,cinnamaldehyde methyl carbonate compounds were obtained by reduction and esterification of cinnamaldehyde.Then the N-acylhydrazone compounds were obtained by the reaction of benzoamide with aldehydes.Finally,alyl amines were obtained by the reaction of cinnamyl methyl carbonate compounds with N-acyl hydrazone compounds.After the reaction model was established,the effects of ligand,palladium source,reaction temperature,reaction time,reaction solvent,substrate ratio and other factors on the reaction were explored with reaction conditions optimized.Under the optimum reaction conditions,the substrate was further expanded,and good yield was obtained,and the highest yield was 99.4%.