The Synthesis Of Pyridylcyclopropyl Ester And (Benzenesulfonyl) Difluoromethyl Thioethers

This report is divided into three major chapters,each of which is divided into two parts:the synthesis of pyridylcyclopropyl ester and the synthesis of?benzenesulfonyl?difluoromethyl thioethers from??difluoromethyl?sulfonyl?benzene and organothiocyanates generated in situ.The synthesis of pyridylcyclopropyl ester via decarboxylation is a challenge in synthetic chemistry.Carboxylic acid is a very cheap and readily available raw material,and the decarboxylation reaction in chemical reactions has been closely watched by researchers.At the same time,nitrogen-containing compounds are also the focus of researchers' attention,and both are closely related to amino acids and drugs.The coupling reaction between the two has also been reported,and researchers have been working to simplify the reaction conditions and make the reaction conditions more gentle.However,there are still some problems that have not been resolved.For example,the decarboxylation of the tertiary carbon of a multivalent ring with an electron-withdrawing group is rarely reported.In this paper,a three-membered cyclic carboxylic acid ester compound containing pyridine is synthesized.At the same time,the synthesis of?benzenesulfonyl?difluoromethyl thioethers was also reported.The "SCF₂" part is a key element in the study of pharmaceuticals and agrochemicals,and therefore the difluoromethylthio group has attracted a great deal of interest from researchers.This article reports the synthesis of various benzenesulfonyl difluoromethyl sulfides.Since benzenesulfonic acid is easily stripped off,this can be considered as a potential difluoromethylthio reagent,which itself is also a diversified difluoromethyl sulfide group.