Lewis Acid Catalyzed The Multicomponent Reaction Of Aldehyde And Styrene To Construct Allylamines And Furanolides

The asymmetric synthesis of allyl amines is an important research field in modern organic synthesis,mainly due to the important role of the functional groups in various synthetic intermediates and bioactive agents,which can be used to synthesize lactam,Phenols,indoles,alkaloids,amino acids and the like have important biological activity.In view of the important research value of allylamine compounds,this paper explores the direct allylation of chiral oxazolidinones with aldehydes and olefins catalyzed by iodine.The reaction is carried out without the use of any base or metal,converting the chiral oxazolidinone directly to N-allylated oxazolidinone,and separating the diastereomer by simple column chromatography.the main contents of this paper are composed of the following aspects:1.A series of chiral allylamine compounds with good chemical selectivity were synthesized by direct allylation of chiral oxazolidinone,aldehydes and substituted styrene.The reaction substrate is well tolerated,the condition is mild and the substrate is simple and easy to obtain.The structure of the product was characterized by ¹H NMR,¹³C NMR and HRMS.2.A series of ethyl 3-benzoyl-5-oxotetrahydrofuran-2-carboxylate was obtained by the intermolecular cyclization of substituted styrene and ethyl oxalate using Bi（OTf）₃ as catalyst and dioxane as solvent.The structure of the product was characterized by ¹H NMR,¹³C NMR and HRMS.