Preparation And Ectopic Bone Capacity Analysis Of Porosity SFP/CS/GP Biomimetic Artificial Scaffold

With bone tissue engineering researcher depth,synthetic bone graft material rose to a new development stage.Bone tissue engineering used for bone repair material was accepted by the majority of people,and the bone scaffold is the center and core part.Cell scaffold material was the adhesion base for damage repair process and having the role of cell proliferation,mediated external growth,but also to determine whether the organizational structure of local damage orderly regeneration,a key factor to recovery its continuity.Silkworm silk fibroin is natural secreted protein,has good biodegradability,biocompatibility,source widely,is a better medical materials for cell culture scaffold.Fibroin protein and fat cells culturing confirmed fibroin can provide support for cells adhere,differentiation and proliferation.Polymer composite materials has become a hot research of bone tissue engineering scaffold material,so in view of the advantages of silk fibroin as bone tissue engineering materials,this study intends to use chitosan(CS),nanowires fibroin(SFP),glycerol phosphate Sodium(GP)preparation of porous SFP/CS/GP hydrogel scaffold.Characterization and correlation properties of the gel scaffold was evaluated comparing different aperture ratio of silk fibroin scaffolds,porosity,mechanical properties and biocompatibility,provide a new therapeutic materials for clinical treatment of bone defects.The study materials for different SFP proportions,characterization and performance analysis in different proportions SFP stent,results showed 40% SFP and 60% SFP scaffold has significant dominance on aperture containing porosity,degradation and mechanical properties.Porous SFP/ CS/GP biomimetic scaffolds have good biocompatibility and tissue compatibility;it is an ideal scaffold for bone tissue engineering.