Research On Molecular Communication Based On Complex Signals Of Bone Morphogenetic Proteins

Nanotechnology has provided new solutions for several applications in the fields of biomedicine,industry and military.A nanomachine is a tiny component composed of a set of molecules,being an artificial or biological nanoscale device capable of performing simple calculations,sensing,or driving.And it is considered to be the most basic functional unit of a nanonetwork.The ability of nano-networks composed of engineering biological nanomachines to communicate with biological systems will play a huge role in the future,such as monitoring human conditions,regenerating biological tissues and organs,and interconnecting artificial devices with the nervous system.Due to the size and energy efficiency of existing communication equipment,it cannot be applied to nano-level communication between nano-machines,so molecular communication(MC)is proposed to replace the traditional electromagnetic communication.MC is a new paradigm.It is a technology that uses biochemical molecules as information carriers and uses the communication mechanism existing in biological cells to form distributed nano-networks through interconnected nano-machines for communication.Based on the concept,application and development prospects of molecular communication,this thesis presents the signal transduction process of bone morphogenetic proteins(BMPs).According to the biological background of the complex signal of BMP,a MC model based on BMP was established,and the error rate performance of the system was simulated.Based on the communication idea of BMP decoding and forwarding,according to Shannon's capacity theorem and Fick's law,the interruption behavior of the fading channel of BMP was studied,considering the distribution characteristics of channel gain.Finally,based on information theory and Fisher information matrix,the complexity of BMP signal channels was analyzed.The work in the thesis has certain reference value for the performance optimization and complexity analysis of the bone morphogenetic protein signal system,which is helpful for the further study of BMPs signal from the communication point.The exchange of information and commands between networked nanomachines will enable nanomachines to work in a cooperative or synchronized manner,perform more complex tasks,and help study drug delivery in vivo or diagnosis of certain diseases.