Studies On Preparation And Property Of Carbohydrate Responsive Polymer Photonic Crystals

Carbohydrates,as large and diverse molecules,play numerous roles in living systems.They are known as the structural materials and energy substances of life.Meanwhile,because of their ubiquity on cell surfaces,they are the key components of biological interfaces.As a result of their presence at such interfaces,carbohydrates are fully involved in the molecular recognition and signaling processes in the life.Therefore,the recognition or detection of carbohydrates in the biology has already become one of the key contents of life science.Although the difference between types of carbohydrates only lies on a hydroxyl orientation in the carbohydrates’ structure,the very small difference still may cause a series of different physiological reactions,and it may also make the recognition in aqueous solution become more difficult.However,comparing with other carbohydrate recognition systems,which have the characteristics of slow responses and only microscopic visibility,photonic crystals,as a novel artificial microstructural material,have the outstanding properties of rapid responses to the external environmental changes such as carbohydrate solution as well as macroscopic visibility.Photonic crystals show a very special advantage in the development of carbohydrates recognition and detection.The interactions between carbohydrates and peptides or amino acids play a significant role in life.Advances in this area are likely not only to provide insight into the molecular recognition phenomena,but also to facilitate the development of new therapeutics or chemosensors.Thus we have carried out a comparative study on the carbohydrate responsive photonic crystals which are based on the dipeptide and amino acid respectively.The results are as follows:(1)We have synthetized PS@P(AA-DF)polymer spheres with the core-shell structureusing β-Asp-Phe as the functional monomer,and then fabricated a novel carbohydrate responsive photonic crystal film by the method of vertical deposition.By the tests of SEM,reflection spectrum and so on,we find out that β-Asp-Phe monomer has the property of carbohydrate response,and different monosaccharides or disaccharides show different responsive intensities to β-Asp-Phe.Comparing with Glucose,disaccharides show stronger responsive intensity,but the responsive intensity of trisaccharides to β-Asp-Phe is even stronger than disaccharides.(2)We have synthetized PS@P(AA-ACPhe)polymer spheres with the core-shell structureusing ACPhe as the functional monomer,and then fabricated another novel carbohydrate responsive photonic crystal film by the method of vertical deposition.By the tests of SEM,reflection spectrum and so on,we find out that ACPhe monomer has the property of carbohydrate response,and different monosaccharides or disaccharides show different responsive intensities to ACPhe.Comparing with Glucose,disaccharides show stronger responsive intensity.