Porous Aromatic Frameworks For The Applications Of Biology And Medicine

Along with the continuous development of porous materials,medical applications have become one of the scientific interests that chemists have paid most attention to.Porous aromatic frameworks have made significant progress in catalysis,gas storage and separation due to their high specific surface area,good stability and modifiability but less application in biomedicine.This work chooses PAF-1 with different groups preparing functional porous materials for the applications of Biology and Medicine.Herein our research work is presented as follows:1.A series of PAF-1-NH₂ with different numbers of amines are synthesized and ibuprofen is chosen to study influence factors of the drug release properties of PAF-1-NH₂.The results show that the drug loading increases with the increase of the number of amino groups and decreased with the increase of the surface area.Therefore the numbers of active sites are more important influence factor.The highest drug capacity of PAF-1-NH₂ with the most amino groups was 1.203g/g,much higher than other porous organic materials.Drug release experiment results show that drug release increase with the amino groups which are active sites interacted with ibuprofen.The most released amount is 0.83g/g.2.A fluorescent porous aromatic framework with high surface area named PAF-1-5?6?CFL is synthesized for detecting iron?III?ions,using PAF-1 modified5?6?-Carboxyfluorescein.The fluorescence intensity of PAF-1-5?6?CFL with different concentration of iron?III?ion is measured.The result shows that the quenching coefficient is11865 and the detection limit is 3.8×10^-5M.The luminescent sensing ability of the PAF-1-5?6?CFL for detecting different metal ions is investigated.Moreover,a series of competition experiments to test the luminescence changes are performed in the presence of other metal ions.The fluorescence quenching does not change after adding other metal ions(K⁺,Mn²⁺,Na⁺,Al³⁺,Zn²⁺,Ca²⁺,Ni²⁺).The results reveal that PAF-1-5?6?CFL show high sensitivity and selectivity for sensing of Fe³⁺.3.A diverse functional PAF via postsynthetic modification of PAF-1 is obtained using folic acid and little fluorescein,named PAF-1-FA?FLU?.The characterization of IR and N₂absorption demonstrate the composition of PAF-1-FA?FLU?and the BET surface area is703m²/g.The result shows that PAF-1-FA?FLU?is suitable for biological experiments due to its appropriate size.When PAF-1-FA?FLU?is addedto the medium of cancer cell for several minutes,the material particles gather on the surface of cell.Loading of Doxorubicin hydrochloride in PAF-1-FA?FLU?was 10.67%,higher than some previously reported MOFs.In conclusion,PAF-1-FA?FLU?has great potential as targeted anticancer.