Detection Of Gene Regulatory Relationships Based On ODE Model With Continuous Time-Lag

Over the past years,there are many studies on the detection of regulatory relation-ships between genes.This paper mainly proposed an Ordinary Differential Equation model with continuous time-lag to describe the relationships between genes,then did sim-ulations and predicted whether two genes of real data have the regulatory relationship.Firstly,we construct an Ordinary Differential Equation model with continuous time-lag.Secondly,we generate the synthetic data with or without the regulatory relationship based on the real data from biology experiments.Thirdly,we apply our proposed model to the synthetic data,solve the relevant parameters,and use SVM to predict whether two genes have the regulatory relationship or not.The result shows the accuracy of prediction is 89.5%.Then,we compare the performance of our model with that of linear model using the same synthetic data.Finally,we apply our model to real data to determine whether two genes have the regulatory relationship.