The Relationship Between CFL1 And PGK1 And Radiosensitivity And Prognosis Of Human Glioma

Background and purpose: Glioma is the most common malignancy in central nervous system(CNS).On account of its resistance to treatment,glioma is famous for high mortality.Radiotherapy is the standard treatment for glioma.Thus it is essential to find a biomarker as the predictor for radiosensivility.Previously,Cofilin-1(CFL1)and Phosphoglycerate kinase 1(PGK1)has been revealed that was over-expressed in radioresistant astrocytoma.Methods: In this study,the CFL1 and PGK1 expression of 113 glioma tissues were measured by ELISA method.The association between the expressions of these two proteins and radiosensitivity was analyzed by mean test and multivariate logistic regression in 85 irradiated patients.The survival analysis was performed in and 113 glioma patients respectively.The relationship between protein expression and clinical parameters was explored in irradiated 85 patients and overall 113 patients,respectively,and the correlation between CFL1 and PGK1 were determined as well.Results: Our results showed that the expression of CFL1 and PGK1 were significantly higher(p < 0.001)in radioresistant patients than others.The multivariate Logistic regression demonstrated that the expression of CFL1(p < 0.001)and PGK1(p < 0.001)were associated with radioresistance in glioma.The multivariate Cox regression in overall survival suggested that CFL1 expression or PGK1 expression could be the independent prognosis factor for poor prognosis in 85 glioma patients.In addition,CFL1 expression was positively correlated with PGK1 expression in glioma.Conclusion: The results suggested that as promising indicators,CFL1 and PGK1 could be used to evaluate glioma radiosensitivity and prognosis.These two proteins could also be the potential therapeutic targets of glioma.