Correlation Between IL-6-572C/G And IFNAR1-168G/C Gene Polymorphisms And HBV Infection In Yunnan Yi And Han Populations

Objective To explore the association between IL-6-572C/G(rs1800796)as well as IFNAR1-168C/G(rs2257167)and prognosis after hepatitis B virus infection in Dai and Han ethnicities in Yunnan Province.Methods Blood samples were collected from 300 Dai ethnicities and 300 Han ethnicities,each include 100 healthy controls and 200 infected individuals(include 100 spontaneouhes recovery patients and 100 chronic HBV infected patients).Polymerase Chain Reaction-Restriction Fragment Length Polymorphism(PCR-RFLP)and DNA Sequencing were used to identify gene type.Results In Dai ethnicities,the research demonstrates that no significant differences were found between genetic polymorphism of-572C/G and prognosis after hepatitis B virus infection(healthy controls VS HBV infected individuals,χ2==0.287,P=0.866;spontaneouhes recovery patients VS chronic HBV infected patients,χ2=4.798,P=0.091).The differences between pontaneouhes recovery patients vs chronic HBV infected patients and healthy controls VS HBV infected individuals in C and G allels is not statistically significant(P>0.05).Meanwhile,GG genotypes is a vital protective factor for the person who developed into chronic HBV infected patient under the G allele dominance model(GG+CG/CC)(χ2=4.982,P=0.026,OR=0.501,95%CI=0.273-0.919).In Han ethnicities,there are no statistically significant for IL-6-572C/G genotype and allele distribution in each group(P>0.05),as well as the C allele recessive mode and C allele dominance modem(P>0.05).For the above four indictors,IFNAR1-168-C/G have no statistically significant in Dai and Han ethnicities(P>0.05).Conclusion The GG+CG genotype of IL-6-572C/G maybe a protective factor for the Dai ethnicities who infected HBV virus to develop into chronic HBV patients.However,there are no significant association between IFNAR1-168G/C polymorphism and prognosis after hepatitis B virus infection in the two ethnicities.