A Retrospective Study Of Cases Of Primary Biliary Cirrhosis (primary Biliary Cholangitis)

Purpose:Clear the clinical characteristics of patients with PBC,the distribution of specific TCM syndromes,and the relationship between TCM syndromes and Child-Pugh liver function grading.And explore the relationship between the various syndromes and a number of physical and chemical indicators,to provide a basis for the standardization of Chinese medicine and the prognosis of patients.Method:Collect medical records of patients who meet the inclusion criteria,the general situation of patients,symptoms,signs,physical and chemical testing results were summarized.In accordance with the《The diagnostic criteria of traditional Chinese medicine Common Syndromes 》[ 1-2 ],included in the study of patients with TCM syndrome diagnosis,the liver function scores were graded and graded according to the Child-Pugh criteria.Used Logistic regression to analyze the correlation between the multiple physical and chemical indicators and the ribs and the TCM syndromes.Results: 1.Among the 96 patients who were enrolled in the study,there were 12 males and 84 females,the ratio of male to female was 1:7,the minimum age of onset was 20 years old,the maximum was 76 years old,the mean age of onset was(56.87 ± 13.57)years old;2.According to the frequency of symptoms,the first six items are:fatigue(93.75%)>anor exia(87.5%)>hpoc-hondrium fullness(81.25%)>skin itching(78.125%)>poor sleep(68.75%)>hypochondrium pain(59.375%);3.Specific TCM syndromes and distribution are:39 cases of patients belong to syndrom-e of stagnation of liver qi and spleen deficiency,15 cases of patients belong to syndrome of yin deficiency of liver and kidney;6 cases of patients belong to syndrome of stagnation of liver qi and blood stasis;23 cases of patients belong to syndrome of dam-pness-heat of liver and gallbladder;13cases of patients belong to syndrome of yang de-ficiency of spleen and kidney;4.Liver function is Child-Pugh A-level patients in 33 cases,liver function is Child-Pugh B-level patients in 51 cases,liver function is Child-Pugh C-level patients in 12 cases,th e Child-Pugh grades of patients with liver-qi deficiency syndrome and liver-kidney-yin deficiency syndrome were Grade A and B,the Child-Pugh grades of patients with dam pness-heat of liver and gallbladder and yang deficiency of spleen and kidney were Gra de B and C,liver function in patients with liver and blood stasis syndrome in thre-e le vels are distributed.5.ALP and ALB were positively correlated with the syndrome of yin deficiency of liv-er and kidney,GGT was positively correlated with the diagnosis of liver depression an-d blood stasis syndrome,TBi L was positively correlated with the diagnosis of hepatobi-liary dampness syndrome,the related predictors of spleen and kidney yang deficiency were ALB,TBi L and spleen area.The regression results of liver depression and spleen deficiency showed that none of the variables was statistically significant.Conclusion: 1.PBC patients most often see the symptoms are:fatigue、anorexia、hypochondrium full-ness、skin itching、poor sleep、hypochondrium pain and loose stools,most patients wit-h liver function are Child-Pugh B;2.The disease mainly involving the liver、spleen and kidney,specific types include stagnation of liver qi and spleen deficiency,yin deficiency of liver and kidney;stagnation o-f liver qi and blood stasis;dampness-heat of liver and gallbladder;yang deficiency of s-pleen and kidney.Patients who belong to stagnation of liver qi and spleen deficiency and yin deficiency of liver and kidney with better prognosis than the syndrome of dampness-heat of liver and gallbladder and yang deficiency of spleen and kidney;3.Patients with ALP and ALB value is higher,the greater the possibility of diagnosis o-f liver and kidney yin deficiency;the greater the GGT value,the greater the likelihood of being diagnosed with liver and blood stasis;the higher the TBi L results,the greater the likelihood of hepatobiliary dampness syndrome;the smaller the ALB value,the grea-ter the TBi L and spleen area values,the greater the likelihood of being diagnosed with spleen and kidney yang deficiency.