Analysis Of Reactivation Of Hepatitis B Virus In Patients With Breast Cancer During Chemotherapy

AIM: To study the reactivation of hepatitis B virus in breast cancer patients receiving chemotherapy with positive HBs Ag and the preventional effect of antiviral treatment.METHODS: 766 breast cancer patients undergoing chemotherapy were reviewed.Of 86 patients with HBs Ag positive with normal liver fuction before chemotherapy,30 patients as therapy group which receive antiviral treatment and 56 patients as control group which did not.These patients were studied and followed up through the treatment.When it is the one week and one month day of every cycle in the course of themotherapy,we tese the liver function and viral load(HBV-DNA),then the HBV reactivation rate were determined.RESULTS: There were 12 of 86 patients with positive HBs Ag had HBV eactivation,1 in therapy group and 11 in control group(3.33% vs19.64%,P=0.003).16(18.6%)patients suffer hepatitis during chemotherapy.Of these 16 patients,in breast cancer patients receiving chemotherapy with positive HBs Ag and 2(6.66%)were in the therapy group(P=0.001).Slight hepatitis is significantly less in therapy group than control group[1(3.33%)vs9(16.07%),P=0.004 ].There is no statistical significace between two groups in moderate 、 severe hepatitis(P>0.05).In control group,there is 9patients occurd chemotherapy delay,while no patient in therapy grroup(P=0.006).CONCLUSION: It conclude that it is necessary for breast cancer patientsto crreen HBVbefore chemotherapy,and preventive antiviral theray significantly reduces the incidence of HBV reactivation for breast cancer patients who are undergoing chemotherapy.