A Retrospective Evaluation Study Of Evidence-based Medicine In The Combination Of Eighteen Anti-Chinese Aconitum With Melon, Fritillary, White Peony, White And Anti-drug

Eighteen incompatible herbs is the synonymous with traditional Chinese medicine incompatibility.From Jin and Yuan Dynasties to today,it has a history of almost a thousand years.Though the theory of Eighteen incompatible herbs has limited clinical application of anti-drug,in ancient and modern times there are some clinical applicationto curing some difficult and complicated diseases.So whether anti-drug can be used in the clinic,ancient physicians have different points of view.Someone thinks using the anti-drug could increase toxicity and reduce the efficacy;someone thinks using the anti-drug could produce mutual stimulation to cure incurable diseases.So anti-drug whether can be used in clinic is a burning question in the medical field.We all know Chinese medicine theory derived from the clinical,and used the clinical applications as the guiding principles,so the eighteen incompatible herbs is a clinic question in final analysis.Although many recent theoretical and experimental study of initial eighteen incompatible herbs is the incompatibility under certain conditions,rather than the absolute incompatibility,there are certain conditions such uncertainties,we can not rush to conduct clinical trials in the crowd otherwise,it would be contrary to the harm principle in medical ethics.Consequently in the crowd at this stage to carry out the eighteen incompatible herbs conditions for application of clinical trials has a certain degree of difficulty,and it is not easy to be pursued.So we try to use Evidence-Based Medicine approach to evaluate eighteen incompatible herbs's clinical application,from the perspective of modern clinical research literature to reveal the clinical applications of eighteen incompatible herbs.Evidence-Based Medicine is a new discipline of clinical medicine developed rapidly in recent years,which has become the new direction of development of international medical research.Evidence-Based Medicine methods which used to evaluate the efficacy and safety of interventions have been generally accepted by the World Health Organization(WHO)and the various countries.[Objective]The topics will systematically accessed on the basis of" aconitum "class of the eighteen incompatible herbs expect pinellia,then research the type of clinical research of" aconitum "class of anti-drug compatibility expect pinellia of combinations to carry out Evidence-Based Medicine evaluation studies.[Method]1.Documentation Systems Retrieval2.Access Database creation3.Statistical description and analysis[Contents]1.From the perspective of Evidence-Based Medicine to launch Systematic reviews toward eighteen incompatible herbs with " aconitum " class expect pinellia anti-drug compatibility combination therapy clinical research safety of the systematic review2.From the perspective of Evidence-Based Medicine to launch systematic review toward eighteen incompatible herbs with " aconitum " class expect pinellia anti-drug compatibility combination therapy clinical research3.Analyzing the research literature characteristic of the compatibility of anti-drug combination of clinical study types and clinical applications of " aconitum " class expect pinellia of eighteen incompatible herbs[Result]1.Documentation Systems Search ResultsSearching the clinical application literature totals up to 1626 pieces.Aconitum and fructus,fritillaria,Japanese ampelopsis root,baiji,and the drug combination tongfang clinical application with 730 references.Aconitum and fructus,fritillaria,Japanese ampelopsis root,baiji and the medicine clinical syndrome differentiation and subtract the application with 896 references.2.Classification of statistical results of the combination of clinical study types of anti-drug compatibilityIn the 1626 pieces documents,the RCT has 423 pieces;the CCT has 81 pieces;the CS has 633 pieces;the CR has 336 pieces and the EX has 153 pieces.3.Database resultsWe establish five databases:RCT database,CCT databsse,CR database,CS database and EX database.The content of the databases contains documents' basic information:the basic information of document,pathogenetic conditions' information,therapeutic effect,situation of anti-drug and the data's extraction.4.Safety evaluation and study of compatibility of anti-drug combinationAconitum class of anti-drug compatibility expect pinellia with the use of literature,only 38 was clearly pointed out that adverse reaction has occurred in the process of clinical treatment.5.Efficacy evaluation results of compatibility of anti-drug combinationBecause of the poor quality of the retrieved literature,we can not conform to the Meta analysis of the basic conditions of evidence-based medicine.6.Anti-drug literature features6.1 Anti-drug compatibility with the clinical treatment of diseasesAconitum and radix trichosanthis are clinically used together mainly to cure the Medicaldiseases such as Diabetes.Aconitum and fructus are clinically used together mainly to cure the Medicaldiseases such asthoracic obstruction.Aconitum and fritillaria are clinically used together mainly to cure the Medicaldiseases such as cough and uroschesis.Aconitum and unibract fritillary bulb are clinically used together mainly to cure the Medicaldiseases such as cough.Aconitum and zhejiang fritillary bulb are clinically used together mainly to cure the Medicaldiseases such as cough and uroschesis.Aconitum and Japanese ampelopsis are clinically used together mainly to cure the Medicaldiseases such as Bi Zheng.Aconitum and baiji are clinically used together mainly to cure the Medicaldiseases such as diarrhea and stomachache.6.2 Anti-drug compatibility with the clinical doseClinical use of anti-drugs with aconitum used dose of 6g and 1 Og;Radix trichosanthis commonly used doses of 10g and 20g;fructus commonly used dose of 15g and 30g;fritillaria commonly used dose of 10g and 12g;Unibract fritillary bulb commonly used doses of 10g.Zhejiang fritillary commonly used doses of 10g.Japanese ampelopsis commonly used doses of 10g.Baiji commonly used doses of 10g.6.3 Anti-drug compatibility with the use of ratioAconitum and radix trichosanthis often compatibility use the ratio of 1:1;Aconitum and fructus often compatibility use the ratio of 1:2;Aconitum and fritillaria often compatibility use the ratio of 2:3;Aconitum and unibract fritillary bulb often compatibility use the ratio of 3:2;Aconitum and zhejiang fritillary bulb often compatibility use the ratio of 1:1;Aconitum and Japanese ampelopsis often compatibility use the ratio of 1:2;Aconitum and baiji often compatibility use the ratio of 1:5.6.4 the anti-drug compatibility with the clinical drug formulations and routes of administrationAconite and radix trichosanthis,fructus,fritillaria,unibract fritillary bulb,zhejiang fritillary bulbon the clinical use often made "soups oral,within the service-based;The remaining one group clinical with the use often made " soups" oral,topical dip made of the proportion of "paste " the use of topical,oral and topical clinical considerable.6.5 Cooked up by the anti-drug compatibility with the use of clinical drug useThe Radix trichosanthis,fructus,fritillaria,unibract fritillary bulb,zhejiang fritillary,Japanese ampelopsis often use the Crude medicine,and the aconitum use the processing drugs.6.6 documented anti-drug quality evaluation of the clinical literatureFrom the published literature of the unit,the quality of journals,published the era of tripartite face of literature quality evaluation shows that the high quality of the literature we retrieved.[conclusion]1.In the anti-drug groups of contracts of "aconitum" class expect pinellia,aconitum and fructus together used mostly widely,followed by aconitum and radix trichosanthis,aconitum and fritillaria,aconitum and baiji,aconitum and Japanese ampelopsis.2.From types of clinical research,the CS documented the most,followed by the RCT literature.3.From the anti-drug use,both in terms of clinical safety and efficacy,we know,in clinical,anti-drug compatibility portfolio in the clinical application is a certain basis,it is feasible and effective.4.Clinical anti-drug use,however,need to be carried out "under certain conditions,a certain range.4.1 Aconitum and radix trichosanthis using together mainly applies to the treatment of internal medicine diseases,for instance diabetes and so on.Aconitum dose more than 6g following and radix trichosanthis more than appropriate application of 10g;The drug combination often use a ratio of 1:1 and 3:5;radix trichosanthis with the use in raw product is better;treatment of diseases made of the decoction,taken orally.4.2 Aconitum and fructus using together mainly applies to the treatment of internal medicine diseases,for instance xiongbi and so on.Aconitum dose more than 6g following and fructus more than 15g application of appropriate;The The drug combination often a 1:2 and 2:3 ratio with the use of compatibility using;fructus with the use in raw product is better;Treatment of diseases made of the decoction,taken orally.4.3 Aconitum and fritillaria using together mainly applies to the treatment of internal medicine diseases,for instance cough and the lung-distension.Aconitum dose more than lOg following and fructus more than appropriate application of 10g;The drug combination often use a 1:2 and 2:3 ratio with the use of compatibility using;fructus with the use in raw product is better;treatment of diseases made of the decoction,taken orally.4.4 Aconitum and Unibract fritillary bulb using together mainly applies to the treatment of internal medicine diseases,for instance cough and the lung-distension.Aconitum dose more than lOg following and fructus more than appropriate application of 10g;The drug combination often use a 1:2 and 2:3 ratio with the use of compatibility using;fructus with the use in raw product is better;Treatment of diseases made of the decoction,taken orally.4.5 Aconitum and Zhejiang fritillary using together mainly applies to the treatment of internal medicine diseases,for instance uroschesis and the lung-distension.Aconitum dose more than 10g following and fructus more than appropriate application of 10g;The drug combination often use a 1:1 ratio-with the use of compatibility using;fructus with the use in raw product is better;treatment of diseases made of the decoction,taken orally.4.6 Aconitum and Japanese ampelopsis using together mainly applies to the treatment of internal medicine diseases,for instance bizheng.Aconitum dose more than 30g following and Japanese ampelopsis more than appropriate application of 10g;The drug combination often use a 1:2 ratio with the use of compatibility using;fructus with the use in raw product is better;treatment of diseases made of the decoction,taken orally.4.7 Aconitum and baiji using together mainly applies to the treatment of internal medicine diseases,for instance diarrhea and stomachache.Aconitum dose more than lOg following and Japanese ampelopsis more than appropriate application of 10g;The drug combination often use a 1:4 and 1:5 ratio with the use of compatibility using;fructus with the use in raw product is better;treatment of diseases made of the decoction,taken orally..5.After finishing the analysis of literature,we found that the existing published eightteen anti-literature,and even Chinese medicine literature in the field of literature quality to be improved in many respects is not precise enough and need further improvement.Such as Chinese medicine concocted medicine,adverse reactions after treatment,the treatment of diseases,disease name standardization situation,some articles did not explicitly mention or non-standard positioning,so many of the problems are difficult to trace.For certain drugs,further research is very unfavorable from the perspective of evidence-based medicine,it is recommended that future researchers have rigorous attitude to quality literature.