The Efficacy Of CPAP In The Treatment Of OSAHS With Hypertension Was Evaluated Based On The Meta-analysis

Obstructive sleep apnea-hypopnea syndrome diseases are not only serious threat to the quality of sleep and health of patients,but also have an adverse impact on the socio-economic,family happiness.The evaluation of therapeutic effect of CPAP is very important for clinical decision making.Use with the subject of many research results are integrated advantages of Meta-analysis method for evaluation of CPAP in combination with conventional antihypertensive drugs for comprehensive curative on obstructive sleep apnea-hypopnea syndrome with hypertension patients in Chinese,For the domestic related to clinical doctors to provide a reference for treatment.The related RCT literature of continuous positive airway pressure on comprehensive curative effect in obstructive sleep apnea hypopnea syndrome with high blood pressure have been searched by computer from Chinese BioMedical literature Database(CBM),Cochrane Library,PubMed,China Academic Journals full-text database,Wangfang Resource Database,Chongqing VIP,and the relevant journals have been retrieved manually.the clinic randomized controlled trials of the treatment effect to OSAHS with hypertension by CPAP were scanned.RCT conformed to the condition were extracted to the quality of research and to be,extracted in literature.The RevMan5.3 software was applied to carry out Meta-analysis,with pooled analysis parameters of the Meta-analysis to explore the therapeutic effect of CPAP combined conventional antihypertensive drugs.A total of 13 articles are identified to meet the inclusion criteria,Meta-analysis data show the indicators differences were statistically significant.Apnea hypopnea index[WMD=-25.19,95%CI(-34.05,-16.33),P<0.00001].The lowest oxygen saturation at night[WMD=17.57,95%CI(11.16,23.98),P<0.00001].Average systolic blood pressure and diastolic blood pressure during the day[WMD=-8.26,95%CI(-11.18,-5.34),P<0.00001 and WMD=-6.42,95%CI(-8.25,-4.60),P<0.00001,respectively],Night average systolic blood pressure and diastolic blood pressure[WMD=-12.92,95%CI(-19.65,-6.19),P<0.0002 and WMD=-6.31,95%CI(-8.53,-4.09),P<0.00001,respectively],24 h average systolic blood pressure and diastolic blood pressure[WMD=-10.28,95%CI(-14.08,-6.48),P<0.00001 and WMD=-6.99,95%CI(-8.88,-5.09),P<0.00001,respectively],the pooled changes after CPAP treatment for OSAHS and hypertension in patients with the indicators of the control group(conventional drug treatment)have improved significantly.The funnel schema was nearly symmetry with little bias.The results indicated a favorable reduction in comprehensive curative with CPAP combined conventional antihypertensive drug treatment in patients with OSAHS and hypertension in Chinese.In order to further clarify the antihypertensive effect of CPAP in treatment of OSAHS with resistant hypertension,to better apply to the clinic,the subject for more than the above problems were made Meta analysisTo systematically evaluate the impact of CPAP on blood pressure in patients with resistant hypertension and OSAHS.Methods The related RCT literature of CPAP on blood pressure in patients with resistant hypertension and OSAHS have been searched by computer from Cochrane Library,PubMed,ScienceDirect,Web of Science,and the relevant journals have been retrieved manually.The clinic randomized controlled trials of the treatment effect to resistant hypertension and OSAHS by CPAP were scanned.RCT conformed to the condition were extracted to the quality of research and to be,extracted in literature.The RevMan5.3 and R3.2.2 software was applied to carry out Meta-analysis.7 studies of the randomized controlled trials are included,Meta-analysis show the pooled estimates of mean change After CPAP treatment for 24-hour ambulatory mean systolic blood pressure(SBP)and mean diastolic blood pressure(DBP)were[WMD=-5.36,95%CI(-8.60,-2.11),P=0.001;I2 70%]and[WMD=-4.21,95%CI(-6.39,-2.04),P=0.00001;I2 79%]respectively;CPAP therapy can significant reduction blood pressure in patients with resistant hypertension and OSAHS.Above two Meta analysis,all showed that CPAP treatment of OSAHS combined with hypertension has certain curative effect,and the effect of OSAHS in patients with hypertension in China is more significant,for CPAP treatment of OSAHS combined with resistant hypertension,it is suggested that the effect of treatment with conventional antihypertensive drugs will be better.