| Objective:Gastroesophageal reflux disease is one of the most common diseases of digestive department.The coincidence of GERD has been gradually increased,as a consequence of the change in life habits and dietary structure.Meanwhile,mental disorders is commonly seen in people with GERD,which has decreased the curative effection of proton pump inhibitors,and most patients have to keep using drugs for a long time.The study aims to observe the efficacy of Chaihu Shugan Powder and Zuoj in Pellet in curing GERD,so as to provide a safe and efficacy strategy for GERD.Method:1.All of the 78 patients with GERD were from Beijing University of Chinese Medicine,Dongzhimen Hospital,Department of Gastroenterology clinic during 2016.01 and 2016.12,and were certificated to be with anxiety or depression by SAS and SDS.The patients were divided into observation group and control group,with 39 patients in each group.Among the patients in the observation group,3 cases were lost,and the results of 36 patients were finally evaluated.Among the patients of the control group,5 patients were lost,and the results of 34 patients were finally evaluated.There were no significant difference between two groups in the aspects of age,gender,pre-treatment total score of symptoms,SAS and SDS(P>0.05).2.Patients in the control group were treated with rabeprazole 20mg,once a day,and patients in the observation group were treated with rabeprazole 20mg,once a day,and Chaihu Shugan powder and Zuojin Pellet,the basic component of which was radix bupleuri 15g,fructus aurantii 15g,radices paeoniae alba 15g,liquorice 10g,ligusticum wallichii 10g,rhizoma cyperi10g,dried tangerine 10g,fructus meliae toosendan 10g,curcuma zedoary 10g,rheum officinale 2g,rhizoma coptidis 6g,evodia rutaecarpa 1g.The duration of both groups were 8 weeks.During the treatment,all of the patients were told to quit smoking and drinking,take in low-fat diet,keep away from cold or spicy food,and not to eat in 3 hours before going to bed.3.All of the statistics were analysed by the software of SPSS 19.0.There is significant difference between 2 groups if P<0.05,and no significant difference between 2 groups if P>0.05.Results:1.The total score of symptoms of patients in both groups were lower than that before treatment.The score of observation group was much lower than that of the control group(P<0.05).2.The score of single symptoms of both groups such as acid reflux,heart-burn,food reflux,eructation,anorexia and epigastric discomfort,stuffiness and throat discomfort,were lower than that before treatment.The score of observation group was much lower than that of the control group(P<0.05).The score of chest pain was lower after treatment than before in observation group(P<0.05),but the score did not changed in control group(P>0.05).3.The endoscopic grading of patients of reflux esophagitis was improved in both groups.The overall effective rate of the observation group was higher than that of the control group.4.The scores of S AS and SDS of both groups were lower than that before treatment.The score of observation group was much lower than that of the control group(P<0.05).5.There was no aggravation of symptoms,new symptoms or adverse reactions during the treatment.Conclusion:Compared with using rabeprazole alone,the strategy of Chaihu Shugan Powder and Zuojin Pellet combined with rabeprazole can improve the symptoms,endoscopic grading and mental disorders of patients with GERD efficiently without severe adverse reactions. |
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