Acupuncture Treatment Of Chronic Pharyngitis Systematic Evaluation

ObjectiveRetrieving and abroad published about acupuncture treatment of chronic pharyngitis (except acute pharyngitis) of randomized controlled trials, incorporate acupuncture or acupuncture combined with drugs and drugs for the treatment of chronic pharyngitis controlled RCTs conducted research on acupuncture improving the clinical efficacy of the use of chronic pharyngitis clinical symptoms were evaluated for acupuncture treatment of chronic pharyngitis provide evidence-based medicine.MethodsL i teratureRetrieval:A comprehensively searchable database:? Chinese Databases:Computer Retrieval China National Knowledge Infrastructure (1995-2016), Wan Fang Database(before February 28,2016), Chinese Biomedical Literature Database (1995-2016) and VIP database (1995-2016);? Foreign Databases:The Cochrane Library(2015), PubMed (1995-2016); EMBASE (1995-2016);? Manual searches of Chengdu University of Traditional Chinese library-related information;? http://scholar.google.com and other network resources as well as conference literature database (CMCC) and gray literature database for supplementary search.Inclusion:Two reviewers according to the present systematic review of the diagnostic criteria, inclusion criteria and exclusion criteria, or filter out all acupuncture treatment of chronic pharyngitis RCTs, such as encountered in the case of disagreement, the two sides discussed a third party or by the arbitration.Data analysis:A systematic review included studies be evaluated with GRADE Level quality evaluation literature,and through the Cochrane Collaboration dedicated statistical package (Review Manager 5.3.5), qualitative and meta-analysis.Results:(1) A total of 21 included in the standard literature, the total sample size of 2,200 subjects, the test group of 1145 cases,1055 cases in the control group. In intervention group,12 articles about acupuncture and drug control,9 articles about acupuncture combining with the foundation treatment and foundation treatment;(2) Main outcome measures the total efficiency of acupuncture and drug group RR=1.29,95%CI[1.22,1.36], acupuncture and moxibustion combined with foundation and foundation treatment control group RR=1.18,95%CI[1.11,1.25]; cure rate analysis, acupuncture and drug group RR=1.97,95% CI [1.66,2.34], acupuncture combined with foundation and foundation treatment in the control group RR=1.51, 95%CI[1.27,1.81];(3) The qualitative analysis of the vascular endothelial cell adhesion molecule (VCAM-1) and 2 serum IL-2 and TNF-a in the treatment of chronic pharyngitis with acupuncture and moxibustion.Gonelusions:(1) Under the premise of the basic treatment, the increase of acupuncture therapy can improve the clinical total effective rate and cure rate, improve the symptoms and signs, the level of evidence for intermediate, recommended;(2) Acupuncture therapy can improve the total effective rate and cure rate of chronic pharyngitis more than western medicine;(3) Under the premise of basic treatment, acupuncture therapy can improve the throat symptoms scale score, but the scale is not standardized, the level of evidence is not high, need to be further studied and improved;(4) Acupuncture therapy in improving chronic pharyngitis vascular endothelial cell adhesion molecule (VCAM-1) and serum IL-2 and TNF-a had more advantages than drug therapy, level of evidence are low or very low, its clinical reliability cannot be assessed, only for clinical provide reference, to be later for the in-depth study;(5) Due to the lack of adverse reaction data, the objective evaluation of the safety of acupuncture treatment for chronic pharyngitis can not be made.