| In general,nanomaterials can be easily divided into four categories,such as nanopowder,nanofibers,Nanomembrane and nanoblock..In this paper,we focuses on the research and application of nanofibers in the field of electrocatalytic sensing.The nanofibers have the characteristics such as large specific surface area,large aspect ratio,high surface energy and activity,fine fiber and high uniformity.At present,nanofibers are mainly used in separation and filtration,biological and medical treatment,polymer enhancement,electronic and optical devices,enzyme and catalysis.Due to its structural characteristics,polycaprolactone has good flexibility and processability,Polycaprolactone(PCL)has excellent biodegradability and good biocompatibility.Polypyrrole(PPy)has the advantages of high conductivity,easy to prepare and easy to dope.It also has good stability and strong electrochemical reversibility.PPy can be applied to biological,ion detection,supercapacitor and antistatic materials.And it also can be used to construct modified electrode materials.Chemically modified electrodes should have good stability and higher sensitivity.The electrostatic spinning method used in this paper is the most widely used and fastest growing method of nanofiber preparation in recent years.A variety of polymer nanofibers can be prepared by this method,which can meet the needs of their applications in different fields.Gold nanomaterials have more unique physical properties and chemical properties than other nanomaterials.Combining this with an electrochemical sensor can not only improve the catalytic performance of the sensor to the analyte,but also increase the selectivity,and increase the reactivity of the sensor to increase the sensitivity.Because of their complex product structure and various valence electron layer configurations,Metal oxides have many important physical and chemical properties and are widely used in the fields of catalysis,gas sensing,optoelectronics,and electrochemistry.Among them,nickel oxide(Ni O)and copper oxide(Cu O)have important applications in energy storage and sensing due to their advantages of low cost,environmental friendliness,and excellent performance,especially in the area of glucose sensors.Based on the above discussion,the master thesis work based on the preparation of electrospun nanofiber membrane electrode and its surface modified noble metal and transition metal oxide nanoparticles,explore the structure of electrochemical sensors for the detection of uric acid(UA),and the construction of enzyme-free glucose sensor.And apply them to practical applications.This paper mainly includes the following three aspects:(1)Cu O/PCL@PPy/ITO electrode was constructed by electrospinning and electrochemical deposition.Copper oxide,which has good catalytic properties for glucose,is deposited on the surface of the fiber uniformly,and a good performance enzyme-free glucose sensor is constructed.The linear range is 2 μM to 6 m M and the minimum detection limit is 0.8 μM.Can be used to detect glucose in low concentrations of saliva.(2)Cu O/Ni O/PCL@PPy/ITO electrode was constructed by electrospinning and electrochemical deposition.The Cu O and Ni O transition metal oxides,which have good catalytic properties for glucose,were deposited on the surface of the fiber uniformly,and a good performance enzyme-free glucose sensor was constructed.The linear range of 6 μM to 0.3 m M and 0.3 m M to 1 m M can be used to detect glucose in low concentrations of saliva and blood.At the same time,the stability of the sensor in the previous work was improved.(3)The nanocomposite Au/PCL@PPy was fabricated by electrospinning and electrochemical deposition.The constructed nanofiber membrane electrode has good electrocatalytic properties for uric acid(UA)and can be rapidly mass produced.In the concentration range of 6 μM ~ 830 μM has a good detection performance and lower detection limit,detection limit of 0.03 μM.At the same time,the sensor has very good reproducibility and stability. |
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